WNT5A Correlates with Clinicopathological Characteristics in GastricCancer: a Meta-Analysis

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/487045.do
DOI
10.1159/000455934
Title
WNT5A Correlates with Clinicopathological Characteristics in GastricCancer: a Meta-Analysis
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Education (No. 2016R1D1A1B03933145) (to S.N.); and the GachonUniversity Gil Medical Center (Grant number: 2016-06) (to S.N.). Authorsthank Curt Balch for editing the draft.
abstract
Background/Aims: Gastric cancer (GC), the third-leading cause of cancer death in the world, is typically diagnosed only in its advanced stages. WNT signaling has been associated with clinicopathological characteristics in diverse cancer types. But the systematic analysis of WNT5A, a member in the signaling, has not been inspected. Thus, our study used a meta-analysis to statistically associate WNT5A expression with GC clinicopathological characteristics.
Methods: For a systematic literature review of GC in combination with the WNT signaling molecule WNT5A, we searched for PubMed, Cochrane Library, and Web of Science. It led to the five cohorts, in four eligible studies, consisting of 1,034 patients (617 WNT5A-positive and 417 WNT5A-negative patients). These patients were inspected by the library "meta" in R software for our meta-analysis. Results: Our meta-analysis, revealed a statistically significant associations of WNT5A-positivity with lymph node metastasis (p=0.0047), some types of Lauren diffuse subtype GCs (p < 0.0001), advanced tumor depth (p < 0.0001), and advanced UICC stages (p=0.0461) with no observation of bias or confounding factors. Conclusions: These results support the feasibility of targeting this embryonic signaling pathway, both for therapy, and as a biomarker to "guide" various individual interventions (i.e., "personalized medicine"). (C) 2017 The Author(s) Published by S. Karger AG, Basel
provenance
Made available in Cube on 2018-09-28T16:23:47Z (GMT). No. of bitstreams: 0
language
English
author
Nam, Seungyoon
Chung, Jun-Won
Yang, Jun-Young
accessioned
2018-09-28T16:23:47Z
available
2018-09-28T16:23:47Z
issued
2017
citation
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY(41): 1
issn
1015-8987
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/487045.do
Funder
교육부
Funding Program
개인기초연구(교육부)
Project ID
1345269876
Jurisdiction
Rep.of Korea
Project Name
Platform construction for network analysis and target compound suggestion by using statistical tests on signaling pathways in gastric cancer
rights
openAccess
subject
WNT5A
Gastric cancer
Lymph node metastasis
Meta-analysis
type
article


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