Whole genome scan reveals the genetic signature of African Ankole cattlebreed and potential for higher quality beef

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/487012.do
DOI
10.1186/s12863-016-0467-1
Title
Whole genome scan reveals the genetic signature of African Ankole cattlebreed and potential for higher quality beef
Description
This work was supported by a grant from the Next-Generation BioGreen 21Program (Project No. PJ01134905), Rural Development Administration(RDA), Republic of Korea.
abstract
Background: Africa is home to numerous cattle breeds whose diversity has been shaped by subtle combinations of human and natural selection. African Sanga cattle are an intermediate type of cattle resulting from interbreeding between Bos taurus and Bos indicus subspecies. Recently, research has asserted the potential of Sanga breeds for commercial beef production with better meat quality as compared to Bos indicus breeds. Here, we identified meat quality related gene regions that are positively selected in Ankole (Sanga) cattle breeds as compared to indicus (Boran, Ogaden, and Kenana) breeds using cross-population (XP-EHH and XP-CLR) statistical methods.
Results: We identified 238 (XP-EHH) and 213 (XP-CLR) positively selected genes, of which 97 were detected from both statistics. Among the genes obtained, we primarily reported those involved in different biological process and pathways associated with meat quality traits. Genes (CAPZB, COL9A2, PDGFRA, MAP3K5, ZNF410, and PKM2) involved in muscle structure and metabolism affect meat tenderness. Genes (PLA2G2A, PARK2, ZNF410, MAP2K3, PLCD3, PLCD1, and ROCK1) related to intramuscular fat (IMF) are involved in adipose metabolism and adipogenesis. MB and SLC48A1 affect meat color. In addition, we identified genes (TIMP2, PKM2, PRKG1, MAP3K5, and ATP8A1) related to feeding efficiency. Among the enriched Gene Ontology Biological Process (GO BP) terms, actin cytoskeleton organization, actin filament-based process, and protein ubiquitination are associated with meat tenderness whereas cellular component organization, negative regulation of actin filament depolymerization and negative regulation of protein complex disassembly are involved in adipocyte regulation. The MAPK pathway is responsible for cell proliferation and plays an important role in hyperplastic growth, which has a positive effect on meat tenderness.
Conclusion: Results revealed several candidate genes positively selected in Ankole cattle in relation to meat qua
provenance
Made available in Cube on 2018-09-28T16:22:54Z (GMT). No. of bitstreams: 0
language
English
author
Taye, Mengistie
Kim, Jaemin
Yoon, Sook Hee
Lee, Wonseok
Hanotte, Olivier
Dessie, Tadelle
Kemp, Stephen
Mwai, Okeyo Ally
Caetano-Anolles, Kelsey
Cho, Seoae
Oh, Sung Jong
Lee, Hak-Kyo
Kim, Heebal
orcid
Taye, Mengistie/0000-0001-6795-9943
accessioned
2018-09-28T16:22:54Z
available
2018-09-28T16:22:54Z
issued
2017
citation
BMC GENETICS(18)
issn
1471-2156
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/487012.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345274045
Jurisdiction
Rep.of Korea
Project Name
Department of Agricultural Biotechnology
rights
openAccess
subject
African cattle
Ankole cattle
Meat quality
Sanga cattle
XP-CLR
XP-EHH
type
article


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