Whole brain volume changes and its correlation with clinical symptomseverity in patients with schizophrenia: A DARTEL-based VBM study

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/487009.do
DOI
10.1371/journal.pone.0177251
Title
Whole brain volume changes and its correlation with clinical symptomseverity in patients with schizophrenia: A DARTEL-based VBM study
Description
This research was supported by the National Research Foundation of Korea(NRF) grants funded by the Ministry of Education (2014R1A1A2006730) andChonnam National University Research Fund for JNU distinguished researchemeritus professor (2017-2019).
abstract
The purpose of this study was to evaluate gray matter (GM) and white matter (WM) volume alterations in whole-brain structures in patients with schizophrenia and healthy controls using voxel-based morphometry (VBM), and further to assess the correlation between GM and WM volume variations and symptom severity in schizophrenia. A total of 22 patients with schizophrenia and 22 age-matched healthy controls participated. Magnetic resonance image data were processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Patients with schizophrenia exhibited significantly decreased GM volumes of the insula, superior temporal gyrus (STG), gyrus rectus, and anterior cingulate cortex (ACC) compared with healthy controls. The GM volumes of the STG and gyrus rectus were negatively correlated with the positive scales on the Positive and Negative Syndrome Scale (PANSS) and those of the STG and ACC were negatively correlated with the negative scales. The durations of illness in schizophrenia were negatively correlated with the GM volumes of the insula, STG, and ACC. Patients with schizophrenia exhibited significantly decreased WM volumes of the superior frontal gyrus, inferior temporal gyrus, and STG. The WM volumes of the STG were negatively correlated with the duration of illness. Our findings suggest that GM and WM volume abnormalities in the STG are associated with the psychopathology of schizophrenia.
provenance
Made available in Cube on 2018-09-28T16:22:49Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Gwang-Won
Kim, Yun-Hyeon
Jeong, Gwang-Woo
accessioned
2018-09-28T16:22:49Z
available
2018-09-28T16:22:49Z
issued
2017
citation
PLOS ONE(12): 5
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/487009.do
Funder
교육부
Funding Program
이공학학술연구기반구축
Project ID
1345256535
Jurisdiction
Rep.of Korea
Project Name
Neural mechanism and cellular metabolomics on hypofunction of working memory maintenance in patients with generalized anxiety disorder and obsessive compulsive disorder
rights
openAccess
type
article


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