Weissella cibaria WIKIM28 ameliorates atopic dermatitis-like skinlesions by inducing tolerogenic dendritic cells and regulatory T cellsin BALB/c mice

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486993.do
DOI
10.1038/srep40040
Title
Weissella cibaria WIKIM28 ameliorates atopic dermatitis-like skinlesions by inducing tolerogenic dendritic cells and regulatory T cellsin BALB/c mice
Description
This research was supported by a grant from the World Institute ofKimchi funded by the Ministry of Science, ICT and Future Planning(KE1501-2), Republic of Korea.
abstract
The occurrence of atopic dermatitis (AD), a chronic inflammatory skin disease, has been increasing steadily in children and adults in recent decades. In this study, we evaluated the ability of the lactic acid bacterium Weissella cibaria WIKIM28 isolated from gatkimchi, a Korean fermented vegetable preparation made from mustard leaves, to suppress the development of AD induced by 2,4-dinitrochlorobenzene in a murine model. Oral administration of W. cibaria WIKIM28 reduced AD-like skin lesions, epidermal thickening, and serum immunoglobulin E levels. Furthermore, the production of type 2 helper T (Th2) cytokines such as interleukin (IL)-4, IL-5, and IL-13 decreased in peripheral lymph node cells. Moreover, the intake of W. cibaria WIKIM28 increased the proportion of CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells in mesenteric lymph nodes (MLNs) and IL-10 levels in polyclonally stimulated MLN cells. In conclusion, the oral administration of W. cibaria WIKIM28 isolated from gatkimchi ameliorated AD-like symptoms by suppressing allergic Th2 responses and inducing Treg responses. These results suggest that W. cibaria WIKIM28 may be applicable as a probiotic for the prevention and amelioration of AD.
provenance
Made available in Cube on 2018-09-28T16:22:24Z (GMT). No. of bitstreams: 0
language
English
author
Lim, Seul Ki
Kwon, Min-Sung
Lee, Jieun
Oh, Young Joon
Jang, Ja-Young
Lee, Jong-Hee
Park, Hae Woong
Nam, Young-Do
Seo, Myung-Ji
Roh, Seong Woon
Choi, Hak-Jong
orcid
lee, Jong-hee/0000-0001-9938-1306; Seo, Myung-Ji/0000-0003-4100-1504
accessioned
2018-09-28T16:22:24Z
available
2018-09-28T16:22:24Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486993.do
Funder
미래창조과학부
Funding Program
한국기초과학지원연구원연구운영비지원
Project ID
1711047344
Jurisdiction
Rep.of Korea
Project Name
Construction and operation of analytical system for national disaster preparedness
rights
openAccess
type
article


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