Vitamin D deficiency is significantly associated with depression inpatients with chronic kidney disease

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486932.do
DOI
10.1371/journal.pone.0171009
Title
Vitamin D deficiency is significantly associated with depression inpatients with chronic kidney disease
abstract
Background
Depression is reported to be the most common psychological problem in patients with chronic kidney disease (CKD). Several studies have reported that lower levels of serum vitamin D are significantly associated with depression. Both vitamin D deficiency and depression are prevalent in patients with CKD, yet the relationship between these two factors remains poorly understood. This study aimed to investigate the association between vitamin D levels and depression among CKD patients.
Methods
Totally, 21,257 individuals who participated in the Korean National Health and Nutrition Examination Survey (KNHANES V, VI) from 2010-2014 were screened for the study; 533 CKD patients were included. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D3 [25(OH) D3] <= 10 ng/mL. Patients were divided into vitamin D deficient or sufficient groups. Depression was screened for using the Korean version of the WHO Composite International Diagnostic Interview-Short Form. The association between vitamin D deficiency and depression was evaluated by multivariate logistic regression analysis.
Results
The mean participant age was 70.1 +/- 9.4 years; 262 patients (49.2%) were male. The median 25(OH) D-3 level was 19.1 +/- 6.9 ng/mL. The prevalence of depression was higher in CKD patients than in the general population (14.3 vs. 11.1%, P = 0.03). Additionally, the prevalence of depression was significantly higher in CKD patients with (vs. without) vitamin D deficiency (32.5% vs. 50.0%, P < 0.001). Multivariate logistic regression analysis showed that vitamin D deficiency was a significant independent predictor of depression after adjusting for confounding factors
Conclusion
Depression was highly prevalent in CKD patients, in whom vitamin D deficiency was a significant independent predictor of depression. Therefore, management of vitamin D deficiency might help prevent depression in CKD patients.
provenance
Made available in Cube on 2018-09-28T16:20:46Z (GMT). No. of bitstreams: 0
language
English
author
Jhee, Jong Hyun
Kim, Hyoungnae
Park, Seohyun
Yun, Hae-Ryong
Jung, Su-Young
Kee, Youn Kyung
Yoon, Chang-Yun
Park, Jung Tak
Han, Seung Hyeok
Kang, Shin-Wook
Yoo, Tae-Hyun
orcid
Han, Seung Hyeok/0000-0001-7923-5635
accessioned
2018-09-28T16:20:46Z
available
2018-09-28T16:20:46Z
issued
2017
citation
PLOS ONE(12): 2
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486932.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345274063
Jurisdiction
Rep.of Korea
Project Name
Project of Yonsei Medical Science
rights
openAccess
type
article


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