Vitamin C enhances the expression of IL17 in a Jmjd2-dependent manner

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486930.do
DOI
10.5483/BMBRep.2017.50.1.193
Title
Vitamin C enhances the expression of IL17 in a Jmjd2-dependent manner
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Education (NRF-2016R1D 1A1B03934212) and Hallym University(HRF-201612-016).
abstract
Previously, we reported that vitamin C facilitates the CpG demethylation of Foxp3 enhancer in CD4(+) Foxp3(+) regulatory T cells (Tregs) by enhancing the activity of a DNA demethylase ten-eleven-translocation (Tet). However, it is not clear whether vitamin C affects other helper T cell lineages like T helper type 17 (Th17) cells which are related with Tregs. Here, we show that the expression of interleukin-17A (IL17) increases with the treatment of vitamin C but not with other antioxidants. Interestingly, the upregulation of IL17 was not accompanied by DNA demethylation in Il17 promoter and was independent of Tet enzymes. Rather, vitamin C reduced the trimethylation of histone H3 lysine 9 (H3K9me3) in the regulatory elements of the Il17 locus, and the effects of vitamin C were abrogated by knockdown of jumonji-C domain-containing protein 2 (jmjd2). These results suggest that vitamin C can affect the expression of IL17 by modulating the histone demethylase activity.
provenance
Made available in Cube on 2018-09-28T16:20:43Z (GMT). No. of bitstreams: 0
language
English
author
Song, Mi Hye
Nair, Varun Sasidharan
Oh, Kwon Ik
accessioned
2018-09-28T16:20:43Z
available
2018-09-28T16:20:43Z
issued
2017
citation
BMB REPORTS(50): 1
issn
1976-6696
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486930.do
Funder
교육부
Funding Program
개인기초연구(교육부)
Project ID
1345270630
Jurisdiction
Rep.of Korea
Project Name
Clinical application of Treg cells by manipulating the expression of Foxp3
rights
openAccess
subject
H3K9me3
Histone modification
IL17
Jmjd2
Vitamin C
type
article


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