UV irradiation to mouse skin decreases hippocampal neurogenesis andsynaptic protein expression via HPA axis activation

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486808.do
DOI
10.1038/s41598-017-15773-z
Title
UV irradiation to mouse skin decreases hippocampal neurogenesis andsynaptic protein expression via HPA axis activation
Description
This research was supported by a grant from the Korea Health TechnologyR&D Project through the Korea Health Industry Development Institute(KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea(grant number: HI14C1277).
abstract
The skin senses external environment, including ultraviolet light (UV). Hippocampus is a brain region that is responsible for memory and emotion. However, changes in hippocampus by UV irradiation to the skin have not been studied. In this study, after 2 weeks of UV irradiation to the mouse skin, we examined molecular changes related to cognitive functions in the hippocampus and activation of the hypothalamic-pituitary-adrenal (HPA) axis. UV exposure to the skin decreased doublecortin-positive immature neurons and synaptic proteins, including N-methyl-D-aspartate receptor 2 A and postsynaptic density protein-95, in the hippocampus. Moreover, we observed that UV irradiation to the skin down-regulated brain-derived neurotrophic factor expression and ERK signaling in the hippocampus, which are known to modulate neurogenesis and synaptic plasticity. The cutaneous and central HPA axes were activated by UV, which resulted in significant increases in serum levels of corticosterone. Subsequently, UV irradiation to the skin activated the glucocorticoid-signaling pathway in the hippocampal dentate gyrus. Interestingly, after 6 weeks of UV irradiation, mice showed depression-like behavior in the tail suspension test. Taken together, our data suggest that repeated UV exposure through the skin may negatively affect hippocampal neurogenesis and synaptic plasticity along with HPA axis activation.
provenance
Made available in Cube on 2018-09-28T16:17:29Z (GMT). No. of bitstreams: 0
language
English
author
Han, Mira
Ban, Jae-Jun
Bae, Jung-Soo
Shin, Chang-Yup
Lee, Dong Hun
Chung, Jin Ho
orcid
Lee, Darrall/0000-0002-6990-4441
accessioned
2018-09-28T16:17:29Z
available
2018-09-28T16:17:29Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486808.do
Funder
보건복지부
Funding Program
연구중심병원육성
Project ID
1465023068
Jurisdiction
Rep.of Korea
Project Name
Establishment of development platform for targeted therapeutics against aging and chronic tissue inflammation
rights
openAccess
type
article


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