Use of ethanol extracts of Terminalia chebula to prevent periodontaldisease induced by dental plaque bacteria

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486782.do
DOI
10.1186/s12906-017-1619-1
Title
Use of ethanol extracts of Terminalia chebula to prevent periodontaldisease induced by dental plaque bacteria
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Education, Science and Technology (2015R1D1A1A01056946).
abstract
Background: The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been studied. Dental plaque bacteria (DPB) are intimately associated with gingivitis and periodontitis. In the quest for materials that will prove useful in the treatment and prevention of periodontal disease, we investigated the preventive effects of an ethanol extract of Terminalia chebula (EETC) on DPB-induced inflammation and bone resorption.
Methods: The anti-bacterial effect of EETC was analyzed using the disc diffusion method. The anti-inflammatory effect of EETC was determined by molecular biological analysis of the DPB-mediated culture cells. Prevention of osteoclastic bone resorption by EETC was explored using osteoclast formation and pit formation assays.
Results: EETC suppressed the growth of oral bacteria and reduced the induction of inflammatory cytokines and proteases, abolishing the expression of PGE2 and COX-2 and inhibiting matrix damage. By stimulating the DPB-derived lipopolysaccharides, EETC inhibited both osteoclast formation in osteoclast precursors and RANKL expression in osteoblasts, thereby contributing to the prevention of bone resorption.
Conclusions: EETC may be a beneficial supplement to help prevent DPB-mediated periodontal disease.
provenance
Made available in Cube on 2018-09-28T16:16:48Z (GMT). No. of bitstreams: 0
language
English
author
Lee, Jongsung
Nho, Youn Hwa
Yun, Seok Kyun
Hwang, Young Sun
accessioned
2018-09-28T16:16:48Z
available
2018-09-28T16:16:48Z
issued
2017
citation
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE(17)
issn
1472-6882
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486782.do
Funder
교육부
Funding Program
개인기초연구(교육부)
Project ID
1345271660
Jurisdiction
Rep.of Korea
Project Name
Exploring invasive biomarkers through genetic analysis of invaive tumor front
rights
openAccess
subject
Ethanol extract of Terminalia chebula (EETC)
Gingivitis
Periodontitis
Dental plaque bacteria (DPB)
Lipopolysaccharide (LPS)
Inflammation
Osteoclast
type
article


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