Upregulation of prefrontal metabotropic glutamate receptor 5 mediatesneuropathic pain and negative mood symptoms after spinal nerve injury inrats

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486760.do
DOI
10.1038/s41598-017-09991-8
Title
Upregulation of prefrontal metabotropic glutamate receptor 5 mediatesneuropathic pain and negative mood symptoms after spinal nerve injury inrats
Description
We thank Professor Chul Hoon Kim for providing the lentiviral vectors.This work was supported by grants from National Research Foundation ofKorea (2012R1A5A2A44671346 and 2015H1A2A1034977), and Seoul NationalUniversity Hospital Research Fund (320150250).
abstract
Patients with chronic pain easily accompany the negative mood symptoms such as depression and anxiety, and these disturbances in turn affect the aversive perception of pain. However, the underlying mechanisms are largely unknown. We hypothesized that the alteration of metabotropic glutamate receptor 5 (mGluR5) in the brain region underlies such a comorbidity of aversive states. We scanned the brain of chronic neuropathic pain model rats using positron emission tomography (PET) technique with an mGluR5-selective radiotracer [11C] ABP688 and found various brain regions with higher or lower level of mGluR5 compared to control rats. Among the brain areas, a prominent upregulation of mGluR5 was shown in the prelimbic region (PrL) of the medial prefrontal cortex (mPFC) of chronic neuropathic pain animals. A pharmacological blockade of upregulated mGluR5 in the PrL ameliorated the negative symptoms including tactile hypersensitivity and depressive-like behavior, which relieved the subjects from the unpleasant state of chronic neuropathic pain condition. Conversely, lentiviral overexpression of the mGluR5 in the PrL of naive rats successfully induced comorbid pain and negative moods. Our data provide deeper insight into the shared mechanism of pain perception and negative emotions, identifying a therapeutic target for the treatment of chronic pain and mood disorders.
provenance
Made available in Cube on 2018-09-28T16:16:12Z (GMT). No. of bitstreams: 0
language
English
author
Chung, Geehoon
Kim, Chae Young
Yun, Yeong-Chan
Yoon, Sang Ho
Kim, Myoung-Hwan
Kim, Yu Kyeong
Kim, Sang Jeong
orcid
Chung, Geehoon/0000-0003-0771-4391; Kim, Sang Jeong/0000-0001-8931-3713
accessioned
2018-09-28T16:16:12Z
available
2018-09-28T16:16:12Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486760.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345259809
Jurisdiction
Rep.of Korea
Project Name
Study of metabotropic glutamate receptor 5 change in the brain following chronic neuropathic pain
rights
openAccess
type
article


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