Upregulation of interleukin-33 and thymic stromal lymphopoietin levelsin the lungs of idiopathic pulmonary fibrosis

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486757.do
DOI
10.1186/s12890-017-0380-z
Title
Upregulation of interleukin-33 and thymic stromal lymphopoietin levelsin the lungs of idiopathic pulmonary fibrosis
Description
This study was supported by a grant from the National ResearchFoundation of Korea funded by the Korean Government(2013R1A2A2A01068077) and by a research grant from SoonchunhyangUniversity.
abstract
Background: Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; however, their clinical implications remain poorly understood.
Methods: TSLP, IL-25, and IL-33 concentrations were measured in bronchoalveolar lavage fluids obtained from normal controls (NCs; n = 40) and from patients with idiopathic pulmonary fibrosis (IPF; n = 100), non-specific interstitial pneumonia (NSIP; n = 22), hypersensitivity pneumonitis (HP; n = 20), and sarcoidosis (n = 19).
Results: The TSLP and IL-33 levels were significantly higher in patients with IPF relative to the NCs (p = 0.01 and p = 0.0001, respectively), NSIP (p = 4.95E -7 and p = 0.0002, respectively), HP (p = 0.00003 and p = 0.000005, respectively), and sarcoidosis groups (p = 0.003 and p = 0.0001, respectively). However, the IL-25 levels were not significantly different between NC and IPF group (p = 0.432). Receiver operating characteristic curves of the TSLP and IL-33 levels revealed clear differences between the IPF and NC groups (AUC = 0.655 and 0.706, respectively), as well as between the IPF and the other lung disease groups (AUC = 0.786 and 0.781, respectively). Cut-off values of 3.52 pg/mu g TSLP and 3.77 pg/mu g IL-33 were shown to differentiate between the IPF and NC groups with 99.2 and 94.3% accuracy. Cut-off values of 4.66 pg/mu g TSLP and 2.52 pg/mu g IL-33 possessed 99.4 and 93.2% accuracy for differentiating among the IPF and other interstitial lung disease groups.
Conclusions: Innate immune responses may be associated with the development of IPF. Furthermore, the IL-33 and TSLP levels in BAL fluids may be useful for differentiating IPF from other chronic interstitial lung diseases.
provenance
Made available in Cube on 2018-09-28T16:16:07Z (GMT). No. of bitstreams: 0
language
English
author
Lee, Jong-Uk
Chang, Hun Soo
Lee, Hyeon Ju
Jung, Chang An
Bae, Da Jeong
Song, Hyun Ji
Park, Jong Sook
Uh, Soo-Taek
Kim, Young Hoon
Seo, Ki-Hyun
Park, Choon-Sik
accessioned
2018-09-28T16:16:07Z
available
2018-09-28T16:16:07Z
issued
2017
citation
BMC PULMONARY MEDICINE(17)
issn
1471-2466
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486757.do
Funder
보건복지부
Funding Program
보건의료생물자원종합관리
Project ID
1465024977
Jurisdiction
Rep.of Korea
Project Name
2017-보건의료생물자원종합관리를 위한 연구 추진 등
rights
openAccess
subject
IL-25
IL-33
TSLP
IPF
Innate immune response
type
article


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