Undariopsis peterseniana Promotes Hair Growth by the Activation ofWnt/beta-Catenin and ERK Pathways

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486705.do
DOI
10.3390/md15050130
Title
Undariopsis peterseniana Promotes Hair Growth by the Activation ofWnt/beta-Catenin and ERK Pathways
Description
This work was supported by the project titled "Development of Productand Material Promoting Hair-Growth from Jeju Marine Algae" funded by theMinistry of Land, Transport and Maritime Affairs, Korea, and by theBasic Science Research Program through the National Research Foundationof Korea (NRF), funded by the Ministry of Education(NRF-2016R1D1A1B01010337).
abstract
In this study, we investigated the effect and mechanism of Undariopsis peterseniana, an edible brown alga, on hair growth. The treatment of vibrissa follicles with U. peterseniana extract ex vivo for 21 days significantly increased the hair-fiber lengths. The U. peterseniana extract also significantly accelerated anagen initiation in vivo. Moreover, we found that U. peterseniana extract was able to open the K-ATP channel, which may contribute to increased hair growth. The U. peterseniana extract decreased 5 alpha-reductase activity and markedly increased the proliferation of dermal papilla cells, a central regulator of the hair cycle. The U. peterseniana extract increased the levels of cell cycle proteins, such as Cyclin D1, phospho(ser780)-pRB, Cyclin E, phospho-CDK2, and CDK2. The U. peterseniana extract also increased the phosphorylation of ERK and the levels of Wnt/beta-catenin signaling proteins such as glycogen synthase kinase-3 beta (GSK-3 beta) and beta-catenin. These results suggested that the U. peterseniana extract had the potential to influence hair growth by dermal papilla cells proliferation through the activation of the Wnt/beta-catenin and ERK pathways. We isolated a principal of the U. peterseniana extract, which was subsequently identified as apo-9'-fucoxanthinone, a trichogenic compound. The results suggested that U. peterseniana extract may have a pivotal role in the treatment of alopecia.
provenance
Made available in Cube on 2018-09-28T16:14:44Z (GMT). No. of bitstreams: 0
language
English
author
Kang, Jung-Il
Kim, Min-Kyoung
Lee, Ji-Hyeok
Jeon, You-Jin
Hwang, Eun-Kyoung
Koh, Young-Sang
Hyun, Jin-Won
Kwon, Soon-Young
Yoo, Eun-Sook
Kang, Hee-Kyoung
accessioned
2018-09-28T16:14:44Z
available
2018-09-28T16:14:44Z
issued
2017
citation
MARINE DRUGS(15): 5
issn
1660-3397
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486705.do
Funder
국토해양부
Funding Program
미래해양산업기술개발
Project ID
1615002307
Jurisdiction
Rep.of Korea
Project Name
Investigation of hair-growth effect and mechanism on Jeju marine algae
rights
openAccess
subject
Undariopsis peterseniana
hair growth
KATP channel
5 alpha-reductase
dermal papilla cell
Wnt/beta-catenin
apo-9 '-fucoxanthinone
type
article


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