Ultrasound texture analysis: Association with lymph node metastasis ofpapillary thyroid microcarcinoma

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486683.do
DOI
10.1371/journal.pone.0176103
Title
Ultrasound texture analysis: Association with lymph node metastasis ofpapillary thyroid microcarcinoma
Description
This study was supported by the Basic Science Research Program throughthe National Research Foundation of Korea (NRF) by the Ministry ofEducation (2016R1D1A1B03930375). The funders had no role in studydesign, data collection and analysis, decision to publish, orpreparation of the manuscript.
abstract
This retrospective study aimed to evaluate whether ultrasound texture analysis is useful to predict lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC).
This study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. Between May and July 2013, 361 patients (mean age, 43.8 +/- 11.3 years; range, 16-72 years) who underwent staging ultrasound (US) and subsequent thyroidectomy for conventional PTMC <= 10 mm between May and July 2013 were included. Each PTMC was manually segmented and its histogram parameters (Mean, Standard deviation, Skewness, Kurtosis, and Entropy) were extracted with Matlab software. The mean values of histogram parameters and clinical and US features were compared according to lymph node metastasis using the independent t-test and Chi-square test. Multivariate logistic regression analysis was performed to identify the independent factors associated with lymph node metastasis. Tumors with lymph node metastasis (n = 117) had significantly higher entropy compared to those without lymph node metastasis (n = 244) (mean +/- standard deviation, 6.268 +/- 0.407 vs. 6.171 +/-.0.405; P = .035). No additional histogram parameters showed differences in mean values according to lymph node metastasis. Entropy was not independently associated with lymph node metastasis on multivariate logistic regression analysis (Odds ratio, 0.977 [95% confidence interval (CI), 0.482-1.980]; P = .949). Younger age (Odds ratio, 0.962 [95% CI, 0.940-0.984]; P = .001) and lymph node metastasis on US (Odds ratio, 7.325 [95% CI, 3.573-15.020]; P < .001) were independently associated with lymph node metastasis. Texture analysis was not useful in predicting lymph node metastasis in patients with PTMC.
provenance
Made available in Cube on 2018-09-28T16:14:09Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Soo-Yeon
Lee, Eunjung
Nam, Se Jin
Kim, Eun-Kyung
Moon, Hee Jung
Yoon, Jung Hyun
Han, Kyung Hwa
Kwak, Jin Young
accessioned
2018-09-28T16:14:09Z
available
2018-09-28T16:14:09Z
issued
2017
citation
PLOS ONE(12): 4
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486683.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345273930
Jurisdiction
Rep.of Korea
Project Name
Computational Science and Engineering
rights
openAccess
type
article


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