Ultrasonographic Imaging and Anti-inflammatory Therapy of Muscle andTendon Injuries Using Polymer Nanoparticles

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486681.do
DOI
10.7150/thno.18922
Title
Ultrasonographic Imaging and Anti-inflammatory Therapy of Muscle andTendon Injuries Using Polymer Nanoparticles
Description
This work was supported by a grant of Korea Health Technology R&DProject through the Korea Health Industry Development Institute fundedby the Ministry of Health & Welfare (HI13C1370 and HI15C1529) and theTechnology Innovation Program (10052749) funded by Ministry of Trade,Industry and Energy, Republic of Korea.
abstract
Ultrasonography is a reliable diagnostic modality for muscle and tendon injuries, but it has been challenging to find right diagnosis of minor musculoskeletal injuries by conventional ultrasonographic imaging. A large amount of hydrogen peroxide (H2O2) are known to be generated during tissue damages such as mechanical injury and therefore H2O2 holds great potential as a diagnostic and therapeutic marker for mechanical injuries in the musculoskeletal system. We previously developed poly(vanillyl alcohol-co-oxalate) (PVAX), which rapidly scavenges H2O2 and exerts antioxidant and anti-inflammatory activity in H2O2-associated diseases. Based on the notion that PVAX nanoparticles generate CO2 bubbles through H2O2-triggered hydrolysis, we postulated that PVAX nanoparticles could serve as ultrasonographic contrast agents and therapeutic agents for musculoskeletal injuries associated with overproduction of H2O2. In the agarose gel phantom study, PVAX nanoparticles continuously generated CO2 bubbles to enhance ultrasonographic echogenicity significantly. Contusion injury significantly elevated the level of H2O2 in skeletal muscles and Achilles tendons. Upon intramuscular injection, PVAX nanoparticles significantly elevated the ultrasound contrast and suppressed inflammation and apoptosis in the contusion injury of musculoskeletal systems. We anticipate that PVAX nanoparticles hold great translational potential as theranostic agents for musculoskeletal injuries.
provenance
Made available in Cube on 2018-09-28T16:14:06Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Gi-Wook
Kang, Changsun
Oh, Young-Bin
Ko, Myoung-Hwan
Seo, Jeong-Hwan
Lee, Dongwon
accessioned
2018-09-28T16:14:06Z
available
2018-09-28T16:14:06Z
issued
2017
citation
THERANOSTICS(7): 9
issn
1838-7640
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486681.do
Funder
보건복지부
Funding Program
질환극복기술개발
Project ID
1465018720
Jurisdiction
Rep.of Korea
Project Name
Treatment of limb ischemia using antioxidant polymeric prodrug
rights
openAccess
subject
Ultrasonography
Musculoskeletal injury
Polymer nanoparticles
Hydrogenperoxide
CO2 Bubbles
type
article


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