Ulmus macrocarpa Hance Extracts Attenuated H2O2 and UVB-Induced SkinPhoto-Aging by Activating Antioxidant Enzymes and Inhibiting MAPKPathways

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486633.do
DOI
10.3390/ijms18061200
Title
Ulmus macrocarpa Hance Extracts Attenuated H2O2 and UVB-Induced SkinPhoto-Aging by Activating Antioxidant Enzymes and Inhibiting MAPKPathways
Description
This work was supported by "Food Functionality Evaluation program" underthe Ministry of Agriculture, Food, and Rural Affairs, and partly by theKorea Food Research Institute and iPET (Korea Institute of Planning andEvaluation for Technology in Food, Agriculture, Forestry, andFisheries), the High Value-Added Food Technology Development Program(314076-3).
abstract
To protect from reactive oxygen species (ROS) damages, skin cells have evolved to have antioxidant enzymes, such as copper and zinc-dependent superoxide dismutase (SOD1), mitochondrial manganese-dependent superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR), and suppressed the expression of matrix metalloproteinases (MMPs) through the mitogen-activated protein kinase (MAPK) signaling pathways, such as c-Jun N-terminal kinase (JNK) and p38. Bioactive compounds analyses were performed using a high-performance liquid chromatography-photodiode array detector (HPLC-PDA) system. The antioxidant activity of Ulmus macrocarpa Hance (UMH) extracts was estimated in vitro. The anti-aging activity of UMH extracts was estimated in vivo using the SKH-1 hairless mice. The UMH extracts reduced the H2O2-induced intracellular ROS production and the cell damages in human dermal fibroblasts (HDFs). Moreover, the H2O2-induced phosphorylation of JNK and p38 was detected in HDF and UMH extracts blocked the phosphorylation. These results suggest that UMH extracts can reduce the expression of MMPs and the reduced MMPs lead to the inhibition of collagen degradation. In addition, oral administration of the UMH extracts decreased the depth, thickness, and length of wrinkles on UVB exposed hairless mice. Therefore, UMH extracts play an advantage of the functional materials in antioxidant and anti-aging of skin.
provenance
Made available in Cube on 2018-09-28T16:12:49Z (GMT). No. of bitstreams: 0
language
English
author
Choi, Sun-Il
Lee, Jin-Ha
Kim, Jae-Min
Jung, Tae-Dong
Cho, Bong-Yeon
Choi, Seung-Hyun
Lee, Dae-Won
Kim, Jinkyung
Kim, Jong-Yea
Lee, Ok-Hawn
accessioned
2018-09-28T16:12:49Z
available
2018-09-28T16:12:49Z
issued
2017
citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(18): 6
issn
1422-0067
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486633.do
Funder
농림축산식품부
Funding Program
고부가가치식품기술개발
Project ID
1545013751
Jurisdiction
Rep.of Korea
Project Name
농산물의 지표성분 설정 및 피부미용 관련 효능평가
rights
openAccess
subject
Ulmus macrocarpa Hance extracts
human dermal fibroblasts
hairlessmice
antioxidant
anti-aging
type
article


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