Tyrosinase inhibitory components from Aloe vera and their antiviralactivity

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486621.do
DOI
10.1080/14756366.2016.1235568
Title
Tyrosinase inhibitory components from Aloe vera and their antiviralactivity
Description
This study was supported partly by a basic research project (PJ010878)of National Institute of Horticultural and Herbal Science, RDA.
abstract
A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2-9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 +/- 0.9 mu M. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.
provenance
Made available in Cube on 2018-09-28T16:12:30Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Jang Hoon
Yoon, Ju-Yeon
Yang, Seo Young
Choi, Seung-Kook
Kwon, Sun Jung
Cho, In Sook
Jeong, Min Hee
Kim, Young Ho
Choi, Gug Seoun
accessioned
2018-09-28T16:12:30Z
available
2018-09-28T16:12:30Z
issued
2017
citation
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY(32): 1
issn
1475-6366
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486621.do
Funder
농촌진흥청
Funding Program
FTA대응경쟁력향상기술개발
Project ID
1395049579
Jurisdiction
Rep.of Korea
Project Name
Development of chilli pepper viral disease control and prevention system for FTA counterplan
rights
openAccess
subject
Aloe vera
molecular docking
Pepper mild mottle virus
tyrosinase
Xanthorrhoeaceae
type
article


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