Typewriter tinnitus revisited: The typical symptoms and the initialresponse to carbamazepine are the most reliable diagnostic clues

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486619.do
DOI
10.1038/s41598-017-10798-w
Title
Typewriter tinnitus revisited: The typical symptoms and the initialresponse to carbamazepine are the most reliable diagnostic clues
Description
This work was supported by a grant from the Korea Health Technology R&DProject through the Korea Health Industry Development Institute (KHIDI),funded by the Ministry of Health & Welfare, Republic of Korea (grantnumber HI14C2264).
abstract
Although neurovascular compression of the cochlear nerve (NVC-C) presenting as typewriter tinnitus is a discrete disease category, verified diagnostic criteria are lacking. We sought to refine the diagnostic criteria for NVC-C by reference to a relatively large case series. The medical records of 22 NVC-C patients were retrospectively reviewed. Psychoacoustic characteristics, the results of diagnostic work-up (including audiovestibular neurophysiological tests and radiological evaluations), and the initial treatment response to carbamazepine were investigated. All subjects described their tinnitus as a typical "typewriter" or "staccato" sound. Of the 22 subjects, 11 (50%) had histories of vertiginous spells, but none had ipsilesional hearing loss. Vestibular function tests in 11 subjects tested revealed only 2 (18.2%) isolated cervical vestibular evoked myogenic potential abnormalities. Radiological comparisons of the symptomatic and asymptomatic sides, regarding the type of the vascular loop and neurovascular contact, revealed no significant differences. However, all 22 subjects exhibited immediate and marked responses to short-term carbamazepine treatment. Meticulous history-taking in terms of the psychoacoustic characteristics and the response to initial carbamazepine, are more reliable diagnostic clues than are radiological or neurophysiological data in NVC-C subjects. Therefore, the typical psychoacoustic characteristics and the response to initial carbamazepine should be included in the diagnostic criteria.
provenance
Made available in Cube on 2018-09-28T16:12:27Z (GMT). No. of bitstreams: 0
language
English
author
Sunwoo, Woongsang
Jeon, Yung Jin
Bae, Yun Jung
Jang, Jeong Hun
Koo, Ja-Won
Song, Jae-Jin
orcid
Song, Jae-Jin/0000-0002-6631-3232; Jeon, Yung Jin/0000-0002-0285-5534
accessioned
2018-09-28T16:12:27Z
available
2018-09-28T16:12:27Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486619.do
Funder
보건복지부
Funding Program
질환극복기술개발
Project ID
1465021770
Jurisdiction
Rep.of Korea
Project Name
Development of a objective diagnostic method using a novel transcanal sound recording system and spectro-temporal analysis approach
rights
openAccess
type
article


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