TRPV1 Regulates Stress Responses through HDAC2

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486531.do
DOI
10.1016/j.celrep.2017.03.050
Title
TRPV1 Regulates Stress Responses through HDAC2
Description
This research was supported by National Research Foundation of Korea(NRF) grants funded by the Ministry of Education, Science and Technology(MEST), Republic of Korea (2011-0028317 and 2016R1A2B2006474; H.S.) andthe Pioneer Research Center Program of the Ministry of Science, ICT andFuture Planning (2011-0027921; S.J.J.).
abstract
Stress causes changes in neurotransmission in the brain, thereby influencing stress-induced behaviors. However, it is unclear how neurotransmission systems orchestrate stress responses at the molecular and cellular levels. Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel involved mainly in pain sensation, affects mood and neuroplasticity in the brain, where its role is poorly understood. Here, we show that Trpv1-deficient (Trpv1(-/-)) mice are more stress resilient than control mice after chronic unpredictable stress. We also found that glucocorticoid receptor (GR)-mediated histone deacetylase 2 (HDAC) 2 expression and activity are reduced in the Trpv1(-/-) mice and that HDAC2-regulated, cell-cycle- and neuroplasticity-related molecules are altered. Hippocampal knockdown of TRPV1 had similar effects, and its behavioral effects were blocked by HDAC2 overexpression. Collectively, our findings indicate that HDAC2 is a molecular link between TRPV1 activity and stress responses.
provenance
Made available in Cube on 2018-09-28T16:10:06Z (GMT). No. of bitstreams: 0
language
English
author
Wang, Sung Eun
Ko, Seung Yeon
Jo, Sungsin
Choi, Miyeon
Lee, Seung Hoon
Jo, Hye-Ryeong
Seo, Jee Young
Lee, Sang Hoon
Kim, Yong-Seok
Jung, Sung Jun
Son, Hyeon
accessioned
2018-09-28T16:10:06Z
available
2018-09-28T16:10:06Z
issued
2017
citation
CELL REPORTS(19): 2
issn
2211-1247
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486531.do
Funder
과학기술정보통신부
Funding Program
개인기초연구(미래부)
Project ID
1711053807
Jurisdiction
Rep.of Korea
Project Name
Regulation and function of neuritin-induced chromatin remodeling in depression
rights
openAccess
type
article


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