TRIP Database 2.0: A Manually Curated Information Hub for Accessing TRPChannel Interaction Network

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486522.do
DOI
10.1371/journal.pone.0047165
Title
TRIP Database 2.0: A Manually Curated Information Hub for Accessing TRPChannel Interaction Network
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Education, Science and Technology (2008-2005948, 2011-0022437,2010-0019472, and 2012R1A1A2002804). The funders had no role in studydesign, data collection and analysis, decision to publish, orpreparation of the manuscript.
abstract
Transient receptor potential (TRP) channels are a family of Ca2+-permeable cation channels that play a crucial role in biological and disease processes. To advance TRP channel research, we previously created the TRIP (TRansient receptor potential channel-Interacting Protein) Database, a manually curated database that compiles scattered information on TRP channel protein-protein interactions (PPIs). However, the database needs to be improved for information accessibility and data utilization. Here, we present the TRIP Database 2.0 (http://www.trpchannel.org) in which many helpful, user-friendly web interfaces have been developed to facilitate knowledge acquisition and inspire new approaches to studying TRP channel functions: 1) the PPI information found in the supplementary data of referred articles was curated; 2) the PPI summary matrix enables users to intuitively grasp overall PPI information; 3) the search capability has been expanded to retrieve information from 'PubMed' and 'PIE the search' (a specialized search engine for PPI-related articles); and 4) the PPI data are available as sif files for network visualization and analysis using 'Cytoscape'. Therefore, our TRIP Database 2.0 is an information hub that works toward advancing data-driven TRP channel research.
provenance
Made available in Cube on 2018-09-28T16:09:52Z (GMT). No. of bitstreams: 0
language
English
author
Shin, Young-Cheul
Shin, Soo-Yong
Chun, Jung Nyeo
Cho, Hyeon Sung
Lim, Jin Muk
Kim, Hong-Gee
So, Insuk
Kwon, Dongseop
Jeon, Ju-Hong
orcid
Cho, Hyeon Sung/0000-0003-0029-6617
accessioned
2018-09-28T16:09:52Z
available
2018-09-28T16:09:52Z
issued
2012
citation
PLOS ONE(7): 10
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486522.do
Funder
교육과학기술부
Funding Program
일반연구자지원
Project ID
1345174940
Jurisdiction
Rep.of Korea
Project Name
The study on the TRP channel pathophysiology based on network biology
rights
openAccess
type
article


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