trans-11 18:1 Vaccenic Acid (TVA) Has a Direct Anti-Carcinogenic Effecton MCF-7 Human Mammary Adenocarcinoma Cells

Collection with item attached
2014
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486392.do
DOI
10.3390/nu6020627
Title
trans-11 18:1 Vaccenic Acid (TVA) Has a Direct Anti-Carcinogenic Effecton MCF-7 Human Mammary Adenocarcinoma Cells
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Education, Science and Technology (Project No. 010-0006707).
abstract
Trans vaccenic acid (TVA; trans-11 18:1) is a positional and geometric isomer of oleic acid and it is the predominant trans isomer found in ruminant fats. TVA can be converted into cis-9, trans-11 conjugated linoleic acid (c9, t11-CLA), a CLA isomer that has many beneficial effects, by stearoyl CoA desaturase 1 (SCD1) in the mammary gland. The health benefits associated with CLA are well documented, but it is unclear whether trans fatty acids (TFAs) from ruminant products have healthy effects. Therefore, the effects of TVA on the proliferation of MCF-7 human breast adenocarcinoma cells and MCF-10A human breast epithelial cells were investigated in the present study. Results showed that TVA inhibited the proliferation of MCF-7 cells but not MCF-10A cells by down-regulating the expression of Bcl-2 as well as procaspase-9. In addition, the suppressive effect of TVA was confirmed in SCD1-depleted MCF-7 cells. Our results suggested that TVA exerts a direct anti-carcinogenic effect on MCF-7 cells. These findings provided a better understanding of the research on the anti-carcinogenic effects of TVA and this may facilitate the manufacture of TVA/c9, t11-CLA fortified ruminant products.
provenance
Made available in Cube on 2018-09-28T16:06:23Z (GMT). No. of bitstreams: 0
language
English
author
Lim, Ji-Na
Oh, Jin-Ju
Wang, Tao
Lee, Jae-Sung
Kim, Sang-Hun
Kim, Yoon-Jin
Lee, Hong-Gu
orcid
Lee, Jae-Sung/0000-0001-8940-9862
accessioned
2018-09-28T16:06:23Z
available
2018-09-28T16:06:23Z
issued
2014
citation
NUTRIENTS(6): 2
issn
2072-6643
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486392.do
Funder
교육과학기술부
Funding Program
일반연구자지원
Project ID
1345177333
Jurisdiction
Rep.of Korea
Project Name
Study on physiological function and development of reducing technic of high level trans fatty acid (TVA; t11-C18:1, vaccenic acid) in milk
rights
openAccess
subject
apoptotic protein
cancer cells
cis-9
stearoyl CoA desaturase
transfatty acids
trans-11conjugated linoleic acid
type
article


Files in This Item

There are no attached files.