Tracking Perfluorocarbon Nanoemulsion Delivery by F-19 MRI for PreciseHigh Intensity Focused Ultrasound Tumor Ablation

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486384.do
DOI
10.7150/thno.16895
Title
Tracking Perfluorocarbon Nanoemulsion Delivery by F-19 MRI for PreciseHigh Intensity Focused Ultrasound Tumor Ablation
Description
The authors are grateful to the Molecular Imaging Core in the NationalCancer Center, Korea, for experimental support. This research wassupported by a Grant from the National Cancer Center (NCC-1510030).
abstract
Perfluorocarbon nanoemulsions (PFCNEs) have recently been undergoing rigorous study to investigate their ability to improve the therapeutic efficacy of tumor ablation by high intensity focused ultrasound (HIFU). For precise control of PFCNE delivery and thermal ablation, their accumulation and distribution in a tumor should be quantitatively analyzed. Here, we used fluorine-19 (F-19) magnetic resonance imaging (MRI) to quantitatively track PFCNE accumulation in a tumor, and analyzed how intra-tumoral PFCNE quantities affect the therapeutic efficacy of HIFU treatment. Ablation outcomes were assessed by intra-voxel incoherent motion analysis and bioluminescent imaging up to 14 days after the procedure. Assessment of PFCNE delivery and treatment outcomes showed that 2-3 mg/mL of PFCNE in a tumor produces the largest ablation volume under the same HIFU insonation conditions. Histology showed varying degrees of necrosis depending on the amount of PFCNE delivered. F-19 MRI promises to be a valuable platform for precisely guiding PFCNE-enhanced HIFU ablation of tumors.
provenance
Made available in Cube on 2018-09-28T16:06:10Z (GMT). No. of bitstreams: 0
language
English
author
Shin, Soo Hyun
Park, Eun-Joo
Min, Changki
Il Choi, Sun
Jeon, Soyeon
Kim, Yun-Hee
Kim, Daehong
accessioned
2018-09-28T16:06:10Z
available
2018-09-28T16:06:10Z
issued
2017
citation
THERANOSTICS(7): 3
issn
1838-7640
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486384.do
Funder
보건복지부
Funding Program
암연구소및국가암관리사업본부연구운영비지원
Project ID
1465024298
Jurisdiction
Rep.of Korea
Project Name
Management of molecular imaging core(2)
rights
openAccess
subject
Perfluorocarbon nanoemulsion (PFCNE)
F-19 MRI
High Intensity FocusedUltrasound (HIFU)
Tumor Ablation
Diffusion MR
type
article


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