Tracheal reconstruction with a free vascularized myofascial flap:preclinical investigation in a porcine model to human clinicalapplication

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486380.do
DOI
10.1038/s41598-017-10733-z
Title
Tracheal reconstruction with a free vascularized myofascial flap:preclinical investigation in a porcine model to human clinicalapplication
Description
This work was supported by the Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Science, ICT and Future Planning (2015R1C1A1A01051907).
abstract
Although there are various methods for tracheal reconstruction, such as a simple approximation with suturing and coverage with adjacent soft tissue or muscle, large defects >50% of the tracheal length still present a clinical challenge. Tissue engineering, a recent promising way to possibly resolve this problem, requires a long preparatory period for stem cell seeding on a scaffold and relatively invasive procedures for stem cell harvesting. As an alternative, we used a vascularized myofascial flap for tracheal reconstruction. In four porcine models, the deep inferior epigastric perforator (DIEP) was used in two and the superior epigastric artery perforator (SEAP) in two. Transformation of the surface of the transplanted myofascial flap was analyzed in the airway environment. The flaps failed in the DIEP group due to venous congestion. At 12 weeks postoperatively, none of SEAP group showed any signs of respiratory distress; the inner surface of the implant exhibited stratified squamous epithelium with sparse cilia. In the clinical setting, a patient who underwent a tracheal reconstruction with a vascularized myofascial flap and 2-year follow-up was in good health with no respiratory distress symptoms.
provenance
Made available in Cube on 2018-09-28T16:06:03Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Won Shik
Chang, Jae Won
Jang, Woo Soon
Seo, Young Joon
Kang, Mi-Lan
Sung, Hak-Joon
Kim, Da Hee
Kim, Jung Min
Park, Jae Hong
Ban, Myung Jin
Na, Gina
Shin, Seung Ho
Byeon, Hyung Kwon
Koh, Yoon Woo
Kim, Se-Heon
Baik, Hong Koo
Choi, Eun Chang
orcid
Chang, Jae Won/0000-0002-6596-931X; Ban, Myung Jin/0000-0003-2069-2422
accessioned
2018-09-28T16:06:03Z
available
2018-09-28T16:06:03Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486380.do
Funder
과학기술정보통신부
Funding Program
국제연구인력교류
Project ID
1711063593
Jurisdiction
Rep.of Korea
Project Name
항-혈전 및 생분해성 형상기억 고분자 마이크로-니들 혈관문합기 개발
rights
openAccess
type
article


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