Total kidney and liver volume is a major risk factor for malnutrition inambulatory patients with autosomal dominant polycystic kidney disease

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486351.do
DOI
10.1186/s12882-016-0434-0
Title
Total kidney and liver volume is a major risk factor for malnutrition inambulatory patients with autosomal dominant polycystic kidney disease
Description
This work was supported by a grant of the Korea Health Technology R&DProject through the Korea Health Industry Development Institute, fundedby the Ministry of Health and Welfare, Republic of Korea (grant number:HI12C0014). The authors thank A Song Kim, Minyoung Jung, Jiseon Kim,Hyunjoo Kim, and other technicians in the three-dimensional constructionlaboratory of the Department of Radiology, Seoul National UniversityHospital for helping measure liver volume.
abstract
Background: In patients with autosomal dominant polycystic kidney disease (ADPKD), malnutrition may develop as renal function declines and the abdominal organs become enlarged. We investigated the relationship of intra-abdominal mass with nutritional status.
Methods: This cross-sectional study was performed at a tertiary hospital outpatient clinic. Anthropometric and laboratory data including serum creatinine, albumin, and cholesterol were collected, and kidney and liver volumes were measured. Total kidney and liver volume was defined as the sum of the kidney and liver volumes and adjusted by height (htTKLV). Nutritional status was evaluated by using modified subjective global assessment (SGA).
Results: In a total of 288 patients (47.9% female), the mean age was 48.3 +/- 12.2 years and the mean estimated glomerular filtration rate (eGFR) was 65.3 +/- 25.3 mL/min/1.73 m(2). Of these patients, 21 (7.3%) were mildly to moderately malnourished (SGA score of 4 and 5) and 63 (21.7%) were at risk of malnutrition (SGA score of 6). Overall, patients with or at risk of malnutrition were older, had a lower body mass index, lower hemoglobin levels, and poorer renal function compared to the well-nourished group. However, statistically significant differences in these parameters were not observed in female patients, except for eGFR. In contrast, a higher htTKLV correlated with a lower SGA score, even in subjects with an eGFR >= 45 mL/min/1.73 m(2). Subjects with an htTKLV >= 2340 mL/m showed an 8.7-fold higher risk of malnutrition, after adjusting for age, hemoglobin, and eGFR.
Conclusions: Nutritional risk was detected in 30% of ambulatory ADPKD patients with relatively good renal function. Intra-abdominal organomegaly was related to nutritional status independently from renal function deterioration.
provenance
Made available in Cube on 2018-09-28T16:05:16Z (GMT). No. of bitstreams: 0
language
English
author
Ryu, Hyunjin
Kim, Hyosang
Park, Hayne Cho
Kim, Hyunsuk
Cho, Eun Jin
Lee, Kyu-Beck
Chung, Wookyung
Oh, Kook-Hwan
Cho, Jeong Yeon
Hwang, Young-Hwan
Ahn, Curie
orcid
Hwang, Young-Hwan/0000-0001-8935-2659
accessioned
2018-09-28T16:05:16Z
available
2018-09-28T16:05:16Z
issued
2017
citation
BMC NEPHROLOGY(18)
issn
1471-2369
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486351.do
Funder
보건복지부
Funding Program
질환극복기술개발
Project ID
1465023634
Jurisdiction
Rep.of Korea
Project Name
Genotype-phenotype correlation study using next-generation sequencing technique in autosomal dominant polycystic kidney disease
rights
openAccess
subject
Autosomal-dominant polycystic kidney disease
Chronic kidney disease
Gender
Malnutrition
Polycystic liver disease
type
article


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