Timely regulated sorting from early to late endosomes is required tomaintain cerebellar long-term depression

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486284.do
DOI
10.1038/s41467-017-00518-3
Title
Timely regulated sorting from early to late endosomes is required tomaintain cerebellar long-term depression
Description
We thank Dr. George J. Augustine and Dr. Fidel Santamaria for theirvaluable comments regarding the manuscript, and Ms. Yoonhee Kim fortechnical assistance. This work was supported by the World ClassInstitute (WCI) Program of the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology ofKorea (MEST, NRF Grant Number: WCI 2009-003), the Korea Institute ofScience and Technology Institutional Program (Project No. 2E26190), andthe NRF grant funded by MEST (No. 2016008165).
abstract
An important feature of long-term synaptic plasticity is the prolonged maintenance of plastic changes in synaptic transmission. The trafficking of AMPA-type glutamate receptors (AMPARs) is involved in the expression of many forms of synaptic plasticity, yet the subsequent events accomplishing the maintenance of plastic changes in synaptic AMPAR numbers are not fully understood. Here, we find that maintenance of cerebellar long-term depression results from a reduction in the number of AMPARs residing within endocytic recycling pathways. We then develop a genetically encoded, photosensitive inhibitor of late endosome sorting and use this to discover that initial maintenance of long-term depression relies on timely regulated late endosome sorting, which exhibits a threshold as well as switch-like behavior. Thus, our results indicate that recycling AMPAR numbers are reduced by a switching machinery of transient late endosome sorting, and that this process enables the transition from basal synaptic transmission to long-term depression maintenance.
provenance
Made available in Cube on 2018-09-28T16:03:29Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Taegon
Yamamoto, Yukio
Tanaka-Yamamoto, Keiko
orcid
Yamamoto, Yukio/0000-0002-8530-0701; Tanaka-Yamamoto,
Keiko/0000-0002-1246-9784
accessioned
2018-09-28T16:03:29Z
available
2018-09-28T16:03:29Z
issued
2017
citation
NATURE COMMUNICATIONS(8)
issn
2041-1723
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486284.do
Funder
과학기술정보통신부
Funding Program
한국과학기술연구원연구운영비지원
Project ID
1711063828
Jurisdiction
Rep.of Korea
Project Name
mindmap, brainup,RNA
rights
openAccess
type
article


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