Thyroid-Related Protein Expression in the Human Thymus

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486265.do
DOI
10.1155/2017/8159892
Title
Thyroid-Related Protein Expression in the Human Thymus
Description
This work was supported by the National Research Foundation of Korea(NRF) grant for the Global Core Research Center (GCRC) funded by theKorea government (MSIP) (no. 2011- 0030001), Basic Science ResearchProgram through the National Research Foundation of Korea (NRF) fundedby the Ministry of Education (2009-0093820), and Seoul NationalUniversity Cancer Research Institute (cri-12-2 and cri-14-4). MSIP isthe Ministry of Science, ICT & Future Planning.
abstract
Radioiodine whole body scan (WBS), related to sodium iodide symporter (NIS) function, is widely used to detect recurrence/metastasis in postoperative patients with thyroid cancer. However, the normal thymic uptake of radioiodine has occasionally been observed in young patients. We evaluated the expression of thyroid-related genes and proteins in the human thymus. Thymic tissues were obtained from 22 patients with thyroid cancer patients of all ages. The expression of NIS, thyroid-stimulating hormone receptor (TSHR), thyroperoxidase (TPO), and thyroglobulin (Tg) was investigated using immunohistochemistry and quantitative RT-PCR. NIS and TSHR were expressed in 18 (81.8%) and 19 samples (86.4%), respectively, whereas TPO was expressed in five samples (22.7%). Three thyroid-related proteins were localized to Hassall's corpuscles and thymocytes. In contrast, Tg was detected in a single patient (4.5%) localized to vascular endothelial cells. The expression of thyroid-related proteins was not increased in young thymic tissues compared to that in old thymic tissues. In conclusion, the expression of NIS and TSHR was detected in the majority of normal thymus samples, whereas that of TPO was detected less frequently, and that of Tg was detected rarely. The increased thymic uptake of radioiodine in young patients is not due to the increased expression of NIS.
provenance
Made available in Cube on 2018-09-28T16:02:58Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Mi Jeong
Oh, So Won
Youn, Hyewon
Na, Juri
Kang, Keon Wook
Park, Do Joon
Park, Young Joo
Jang, Ja June
Lee, Kyu Eun
Jung, Kyeong Cheon
Chung, June-Key
orcid
LEE, WON-YOUNG/0000-0002-1082-7592; Park, Young Joo/0000-0002-3671-6364;
Lee, Kyu Eun/0000-0002-2354-3599; Kang, Keon Wook/0000-0003-2622-9017;
Youn, Hyewon/0000-0003-1006-2689
accessioned
2018-09-28T16:02:58Z
available
2018-09-28T16:02:58Z
issued
2017
citation
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
issn
1687-8337
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486265.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345274070
Jurisdiction
Rep.of Korea
Project Name
Biomedical Science Project
rights
openAccess
type
article


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