Thyroid fine-needle aspiration biopsy positively correlates withincreased diagnosis of thyroid cancer in South Korean patients

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486264.do
DOI
10.1186/s12885-017-3104-0
Title
Thyroid fine-needle aspiration biopsy positively correlates withincreased diagnosis of thyroid cancer in South Korean patients
Description
This study was supported by a grant from the National R&D Program forCancer Control, Ministry of Health and Welfare, Republic of Korea (No.1420230). The funding source had no role in any of the following: thedesign and conduct of the study; the collection, preparation,management, analysis, and interpretation of data; and the review andapproval of the manuscript.
abstract
Background: The incidence of thyroid cancer among South Koreans is more than 10-fold greater than its incidence in other countries, although its associated mortality rate is similar. Amidst concerns regarding the over-diagnosis of thyroid cancer related to gradually expanded medical testing in South Korea, we hypothesized that the number of thyroid fine-needle aspiration biopsies has led to increased diagnosis of thyroid cancer.
Methods: We used data from the National Health Insurance Service National Sample Cohort 2003-2013, which included all medical claims filed for the 1,122,456 people in a nationally representative sample. We performed a Poisson regression analysis using generalized estimating equation to investigate the relationship between the number of thyroid fine-needle aspiration biopsies and the newly diagnosed cases of thyroid cancer.
Results: The study included 60 annual patients per 100,000 individuals out of 11,024,548 person-years. The number of biopsies per 100,000 patients positively correlated with increased incidence of thyroid cancer diagnosis (per 100 biopsy cases: RR = 1.108; 95% CI: 1.090-1.126; P < 0.0001). Such relationships were greater in males, patients with a higher socioeconomic status, and patients from regions with relatively less accessibility to biopsies.
Conclusion: Our findings suggest that a higher number of thyroid fine-needle aspiration biopsies per 100,000 individuals in a specific Si-Gun-Gu is positively associated with excessively increased diagnosis of thyroid cancer. Regarding the continually increasing thyroid cancer incidence in South Korea, healthcare professionals and policy makers should consider proper guidelines for recognizing the role of thyroid fine-needle aspiration biopsies in the potential over-diagnosis of thyroid cancer.
provenance
Made available in Cube on 2018-09-28T16:02:57Z (GMT). No. of bitstreams: 0
language
English
author
Cho, Yoon Jae
Kim, Do Young
Park, Eun-Cheol
Han, Kyu-Tae
orcid
Park, Eun-Cheol/0000-0002-2306-5398; Han, Kyu-Tae/0000-0002-5817-1203
accessioned
2018-09-28T16:02:57Z
available
2018-09-28T16:02:57Z
issued
2017
citation
BMC CANCER(17)
issn
1471-2407
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486264.do
Funder
보건복지부
Funding Program
암연구소및국가암관리사업본부연구운영비지원
Project ID
1465020486
Jurisdiction
Rep.of Korea
Project Name
...
rights
openAccess
subject
Thyroid cancer
Biopsy
Fine-needle
Health Services Accessibility
Overdiagnosis
type
article


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