Therapeutic properties of Scutellaria baicalensis in db/db miceevaluated using Connectivity Map and network pharmacology

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486185.do
DOI
10.1038/srep41711
Title
Therapeutic properties of Scutellaria baicalensis in db/db miceevaluated using Connectivity Map and network pharmacology
Description
This research was supported by grants K16293 and C16120 from the KoreaInstitute of Oriental Medicine.
abstract
We have reported that an extract of Scutellaria baicalensis (ESB) has effects against obesity and hypertriglyceridemia in type 2 diabetic animal model (db/db mouse). In the present study, we tried to explain the pharmacological effects of ESB by integrating gene expression information from db/db mouse liver with that of ESB-treated HepG2 hepatocellular carcinoma cells. Using Connectivity Map (cmap) analysis, we found an inverse relationship in the pharmaceutical profiles based on gene expression between db/db mouse liver and ESB-treated HepG2 cells. This inverse relationship between the two data sets was also observed for pathway activities. Functional network analysis showed that biological functions associated with diabetes and lipid metabolism were commonly enriched in both data sets. We also observed a similarity in distribution of cmap enrichment scores between db/db mouse liver and human diabetic liver, whereas there was an inverse pattern of cmap enrichment scores in human diabetic liver compared with ESB-treated HepG2 cells. This relationship might explain the pharmacological activities of ESB against db/db mouse and possible effectiveness of ESB against human diabetes. We expect that our approach using in vitro cell lines could be applied in predicting the pharmacological effectiveness of herbal drugs in in vivo systems.
provenance
Made available in Cube on 2018-09-28T16:00:49Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Bu-Yeo
Song, Kwang Hoon
Lim, Chi-Yeon
Cho, Su-In
accessioned
2018-09-28T16:00:49Z
available
2018-09-28T16:00:49Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486185.do
Funder
미래창조과학부
Funding Program
한국한의학연구원연구운영비지원
Project ID
1711047547
Jurisdiction
Rep.of Korea
Project Name
Studies on development of herbal medicine for prevention and treatment to the disease of the aged
rights
openAccess
type
article


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