Therapeutic Potential of Induced Neural Stem Cells for Parkinson'sDisease

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486184.do
DOI
10.3390/ijms18010224
Title
Therapeutic Potential of Induced Neural Stem Cells for Parkinson'sDisease
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Science, information and communications technology (ICT) and futurePlanning (NRF-2014R1A2A1A11050236 grant to DHC, NRF-2014R1A2A1A11050248grant to JL), a grant of the Korea Health Technology R& D Projectthrough the Korea Health Industry Development Institute (KHIDI), fundedby the Ministry of Health & Welfare, Republic of Korea (grant number:HI14C2339), and a grant of the Bio & Medical Technology DevelopmentProgram of the NRF, funded by the Korean Government, MSIP(2015M3A9C7030091 grant to DWH). The funders had no role in studydesign, data collection and analysis, decision to publish, orpreparation of the manuscript.
abstract
Parkinson's disease (PD) is a chronic, neurodegenerative disorder that results from the loss of cells in the substantia nigra (SN) which is located in the midbrain. However, no cure is available for PD. Recently, fibroblasts have been directly converted into induced neural stem cells (iNSCs) via the forced expression of specific transcription factors. Therapeutic potential of iNSC in PD has not been investigated yet. Here, we show that iNSCs directly converted from mouse fibroblasts enhanced functional recovery in an animal model of PD. The rotational behavior test was performed to assess recovery. Our results indicate that iNSC transplantation into the striatum of 6-hydroxydopamine (6-OHDA)-injected mice can significantly reduce apomorphine-induced rotational asymmetry. The engrafted iNSCs were able to survive in the striatum and migrated around the medial forebrain bundle and the SN pars compacta. Moreover, iNSCs differentiated into all neuronal lineages. In particular, the transplanted iNSCs that committed to the glial lineage were significantly increased in the striatum of 6-OHDA-injected mice. Engrafted iNSCs differentiated to dopaminergic (DA) neurons and migrated into the SN in the 6-OHDA lesion mice. Therefore, iNSC transplantation serves as a valuable tool to enhance the functional recovery in PD.
provenance
Made available in Cube on 2018-09-28T16:00:48Z (GMT). No. of bitstreams: 0
language
English
author
Choi, Dong-Hee
Kim, Ji-Hye
Kim, Sung Min
Kang, Kyuree
Han, Dong Wook
Lee, Jongmin
accessioned
2018-09-28T16:00:48Z
available
2018-09-28T16:00:48Z
issued
2017
citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(18): 1
issn
1422-0067
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486184.do
Funder
보건복지부
Funding Program
질환극복기술개발
Project ID
1465021341
Jurisdiction
Rep.of Korea
Project Name
Training Program for Translational Clinical Research Scientists
rights
openAccess
subject
Parkinson's disease
induced neural stem cell
differentiation
reprogramming
transplantation
functional recovery
type
article


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