The stratification of patient risk depending on the size and ratio ofmetastatic lymph nodes in papillary thyroid carcinoma

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486137.do
DOI
10.1186/s12957-017-1141-4
Title
The stratification of patient risk depending on the size and ratio ofmetastatic lymph nodes in papillary thyroid carcinoma
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Education. (2015R1D1A1A01058798).
abstract
Background: The aims of this study were to identify the clinical significances of the size of metastatic lymph node (mLN) and LN ratio (LNR) and to attempt to create a risk stratification for papillary thyroid carcinoma (PTC) patients.
Methods: We investigated the 435 PTC patients who underwent radioactive iodine (RAI) ablation treatment following thyroid surgery. The patients were classified into two groups (micrometastasis (pN1mic) <= 0.2 cm and macrometastasis (pN1mac) > 0.2 cm) and were stratified into the following three risk groups: group I (pN1mic, LNR <= 0.5); group II (pN1mic, LNR > 0.5 or pN1mac, LNR <= 0.5); and group III (pN1mac with LNR > 0.5). And then we investigated the association of the classified groups and variable clinicopathologic factors.
Results: The clinical characteristics such as large tumor size, extrathyroidal extension, higher T stage, and greater number of mLN or LNR were significantly associated with pN1mac. The mean stimulated thyroglobulin levels were increased with the patient risk groups (p = 0.02). The recurrence-free survivals were significantly different between the stratified groups (p = 0.001).
Conclusions: The patient groups I, II, and III may be referred to as low-, intermediate-, and high-risk groups. Clinicians should consider the possibility of recurrence, and the decisions about the application of RAI ablation based on the size of mLN and the patient's risk groups.
provenance
Made available in Cube on 2018-09-28T15:59:31Z (GMT). No. of bitstreams: 0
language
English
author
Hong, Young Ran
Lee, So Hee
Lim, Dong Jun
Kim, Min Hee
Jung, Chan Kwon
Chae, Byung Joo
Song, Byung Joo
Bae, Ja Seong
orcid
Lim, Dong Jun/0000-0003-0995-6482; Jung, Chan Kwon/0000-0001-6843-3708
accessioned
2018-09-28T15:59:31Z
available
2018-09-28T15:59:31Z
issued
2017
citation
WORLD JOURNAL OF SURGICAL ONCOLOGY(15)
issn
1477-7819
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486137.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345274430
Jurisdiction
Rep.of Korea
Project Name
BK21 PLUS Convergence HealthCare Science Program
rights
openAccess
subject
Risk stratification
Prognosis
Lymph node size
Ratio of lymph node
Papillary thyroid carcinoma
type
article


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