The Root Extract of Pueraria lobata and Its Main Compound, Puerarin,Prevent Obesity by Increasing the Energy Metabolism in Skeletal Muscle

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486114.do
DOI
10.3390/nu9010033
Title
The Root Extract of Pueraria lobata and Its Main Compound, Puerarin,Prevent Obesity by Increasing the Energy Metabolism in Skeletal Muscle
Description
This research was supported by the Korean Health Technology R&D Projectthrough the Korean Health Industry Development Institute (KHIDI) fundedby the Ministry of Health & Welfare, Republic of Korea (grant number:HI15C0127).
abstract
Radix Pueraria lobata (RP) has been reported to prevent obesity and improve glucose metabolism; however, the mechanism responsible for these effects has not been elucidated. The mechanism underlying anti-obesity effect of RP was investigated in high-fat diet (HFD) induced obese mice and skeletal muscle cells (C2C12). Five-week-old C5BL/6 mice were fed a HFD containing or not containing RP (100 or 300 mg/kg) or metformin (250 mg/kg) for 16 weeks. RP reduced body weight gain, lipid accumulation in liver, and adipocyte and blood lipid levels. In addition, RP dose-dependently improved hyperglycemia, insulinemia, and glucose tolerance, and prevented the skeletal muscle atrophy induced by HFD. Furthermore, RP increased the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) expression and phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) in skeletal muscle tissues. RP and its main component, puerarin, increased mitochondrial biogenesis and myotube hypertrophy in C2C12 cells. The present study demonstrates that RP can prevent diet-induced obesity, glucose tolerance, and skeletal muscle atrophy in mouse models of obesity. The mechanism responsible for the effect of RP appears to be related to the upregulation of energy metabolism in skeletal muscle, which at the molecular level may be associated with PGC-1 alpha and AMPK activation.
provenance
Made available in Cube on 2018-09-28T15:58:54Z (GMT). No. of bitstreams: 0
language
English
author
Jung, Hyo Won
Kang, An Na
Kang, Seok Yong
Park, Yong-Ki
Song, Mi Young
accessioned
2018-09-28T15:58:54Z
available
2018-09-28T15:58:54Z
issued
2017
citation
NUTRIENTS(9): 1
issn
2072-6643
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486114.do
Funder
보건복지부
Funding Program
한의약선도기술개발
Project ID
1465020721
Jurisdiction
Rep.of Korea
Project Name
Discover of a herbal medicine candidate for obesity using herbs which control energy metabolism and prevent muscle loss
rights
openAccess
subject
Radix Pueraria lobata
obesity
puerarin
skeletal muscle
C2C12
PGC-1alpha
AMPK
type
article


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