The role of myosin II in glioma invasion: A mathematical model

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/486102.do
DOI
10.1371/journal.pone.0171312
Title
The role of myosin II in glioma invasion: A mathematical model
Description
This research (Y. Kim) was supported by Basic Science Research Programthrough the National Research Foundation of Korea (NRF) funded by theMinistry of Education (NRF-2015R1D1A1A01058702) and the faculty researchfund of Konkuk University in 2014. Lee's work was supported by theNational Institute for Mathematical Sciences (NIMS) grant funded byKorea government (A21300000). The funders had no role in study design,data collection and analysis, decision to publish, or preparation of themanuscript.
abstract
Gliomas are malignant tumors that are commonly observed in primary brain cancer. Glioma cells migrate through a dense network of normal cells in microenvironment and spread long distances within brain. In this paper we present a two-dimensional multiscale model in which a glioma cell is surrounded by normal cells and its migration is controlled by cell-mechanical components in the microenvironment via the regulation of myosin II in response to chemoattractants. Our simulation results show that the myosin II plays a key role in the deformation of the cell nucleus as the glioma cell passes through the narrow intercellular space smaller than its nuclear diameter. We also demonstrate that the coordination of biochemical and mechanical components within the cell enables a glioma cell to take the mode of amoeboid migration. This study sheds lights on the understanding of glioma infiltration through the narrow intercellular spaces and may provide a potential approach for the development of antiinvasion strategies via the injection of chemoattractants for localization.
provenance
Made available in Cube on 2018-09-28T15:58:35Z (GMT). No. of bitstreams: 0
language
English
author
Lee, Wanho
Lim, Sookkyung
Kim, Yangjin
accessioned
2018-09-28T15:58:35Z
available
2018-09-28T15:58:35Z
issued
2017
citation
PLOS ONE(12): 2
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/486102.do
Funder
교육부
Funding Program
개인기초연구(교육부)
Project ID
1345269904
Jurisdiction
Rep.of Korea
Project Name
Dynamics of bortezomib-induced ER stress in NFkB-Bcl-2-BAX signaling and development of bortezomib/chemo/radio therapeutic strategies in multiple myeloma, head and neck cancer, and glioblastoma:Mathematical models
rights
openAccess
type
article


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