Self-assembly of free-standing RNA membranes

Collection with item attached
2014
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/484628.do
DOI
10.1038/ncomms5367
Title
Self-assembly of free-standing RNA membranes
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Science, ICT & Future Planning (NRF-2012R1A1A1007520) and alsosupported by the Global Innovative Research Center (GiRC) Programthrough the National Research Foundation of Korea (NRF) funded by theMinistry of Science, ICT & Future Planning (NRF-2012K1A1A2A01056093).
abstract
RNA has emerged as a promising material for nanostructure and microstructure engineering. Although rare, some macroscopic RNA structures have also been constructed using lipid or polymer materials. Here, we report the first example of an enzymatically generated RNA membrane. This robust and free-standing RNA membrane has a macroscopic structure and is generated without any polymer support or complexation. Our RNA membrane is fabricated following two sequential processes, complementary rolling circle transcription and evaporation-induced self-assembly, and its structural and functional properties are rationally controlled by adjusting RNA base pairing. In this study, three types of RNA membranes are fabricated and are used to demonstrate potential applications.
provenance
Made available in Cube on 2018-09-28T15:19:11Z (GMT). No. of bitstreams: 0
language
English
author
Han, Daehoon
Park, Yongkuk
Kim, Hyejin
Lee, Jong Bum
orcid
Kim, Hyejin/0000-0002-7937-2733; Han, Daehoon/0000-0002-2526-3443
accessioned
2018-09-28T15:19:11Z
available
2018-09-28T15:19:11Z
issued
2014
citation
NATURE COMMUNICATIONS(5)
issn
2041-1723
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/484628.do
Funder
미래창조과학부
Funding Program
글로벌연구실사업
Project ID
1711019320
Jurisdiction
Rep.of Korea
Project Name
Development of bio-mimetic self-assembled siRNA carrier
rights
openAccess
type
article


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