Rewiring of PDZ Domain-Ligand Interaction Network Contributed toEukaryotic Evolution

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/484308.do
DOI
10.1371/journal.pgen.1002510
Title
Rewiring of PDZ Domain-Ligand Interaction Network Contributed toEukaryotic Evolution
Description
This work was supported in part by National Research Foundation grants(R31-10100 of the World Class University program, 20100028453 of theNCRC program, and 20100020528) funded by the Korean Ministry ofEducation, Science, and Technology, Seoul National University CancerResearch Institute (cri-10-2), and a POSTECH BSRI grant. The funders hadno role in study design, data collection and analysis, decision topublish, or preparation of the manuscript.
abstract
PDZ domain-mediated interactions have greatly expanded during metazoan evolution, becoming important for controlling signal flow via the assembly of multiple signaling components. The evolutionary history of PDZ domain-mediated interactions has never been explored at the molecular level. It is of great interest to understand how PDZ domain-ligand interactions emerged and how they become rewired during evolution. Here, we constructed the first human PDZ domain-ligand interaction network (PDZNet) together with binding motif sequences and interaction strengths of ligands. PDZNet includes 1,213 interactions between 97 human PDZ proteins and 591 ligands that connect most PDZ protein-mediated interactions (98%) in a large single network via shared ligands. We examined the rewiring of PDZ domain-ligand interactions throughout eukaryotic evolution by tracing changes in the C-terminal binding motif sequences of the PDZ ligands. We found that interaction rewiring by sequence mutation frequently occurred throughout evolution, largely contributing to the growth of PDZNet. The rewiring of PDZ domain-ligand interactions provided an effective means of functional innovations in nervous system development. Our findings provide empirical evidence for a network evolution model that highlights the rewiring of interactions as a mechanism for the development of new protein functions. PDZNet will be a valuable resource to further characterize the organization of the PDZ domain-mediated signaling proteome.
provenance
Made available in Cube on 2018-09-28T15:10:32Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Jinho
Kim, Inhae
Yang, Jae-Seong
Shin, Young-Eun
Hwang, Jihye
Park, Solip
Choi, Yoon Sup
Kim, Sanguk
orcid
Park, Solip/0000-0002-5988-5339; Kim, Sanguk/0000-0002-3449-3814; Yang,
Jae-Seong/0000-0001-9910-3170
accessioned
2018-09-28T15:10:32Z
available
2018-09-28T15:10:32Z
issued
2012
citation
PLOS GENETICS(8): 2
issn
1553-7390
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/484308.do
Funder
교육과학기술부
Funding Program
세계수준의연구중심대학육성_일반(0.5)
Project ID
1345196338
Jurisdiction
Rep.of Korea
Project Name
IT Convergence for Ubiquitous Autonomic Systems
rights
openAccess
type
article


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