Proteome analysis of developing mice diastema region

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/483731.do
DOI
10.5483/BMBRep.2012.45.6.025
Title
Proteome analysis of developing mice diastema region
Description
This work was supported by the National Research Foundation of KoreaGrant (NRF-2010-0004243) funded by the Korean Ministry of Education,Science and Technology, Republic of Korea.
abstract
Different from humans, who have a continuous dentition of teeth, mice have only three molars and one incisor separated by a toothless region called the diastema in the hemi mandibular arch. Although tooth buds form in the embryonic diastema, they regress and do not develop into teeth. In this study, we evaluated the proteins that modulate the diastema formation through comparative analysis with molar-forming tissue by liquid chromatography-tandem mass spectroscopy (LC-MS/MS) proteome analysis. From the comparative and semi-quantitative proteome analysis, we identified 147 up- and 173 down-regulated proteins in the diastema compared to the molar forming proteins. Based on this proteome analysis, we selected and evaluated two candidate proteins, EMERIN and RAB7A, as diastema tissue specific markers. This study provides the first list of proteins that were detected in the mouse embryonic diastema region, which will be useful to understand the mechanisms of tooth development [BMB Reports 2012; 45(6): 337-341]
provenance
Made available in Cube on 2018-09-28T14:54:40Z (GMT). No. of bitstreams: 0
language
English
author
Chae, Young-Mi
Jin, Young-Joo
Kim, Hyeng-Soo
Gwon, Gi-Jeong
Sohn, Wern-Joo
Kim, Sung-Hyun
Kim, Myoung-Ok
Lee, Sanggyu
Suh, Jo-Young
Kim, Jae-Young
accessioned
2018-09-28T14:54:40Z
available
2018-09-28T14:54:40Z
issued
2012
citation
BMB REPORTS(45): 6
issn
1976-6696
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/483731.do
Funder
교육과학기술부
Funding Program
2단계연구중심대학육성(0.5)
Project ID
1345196498
Jurisdiction
Rep.of Korea
Project Name
KNU School of Dentistry BK21
rights
openAccess
subject
Diastema
EMERIN
RAB7A
Tooth development
type
article


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