Progression of Aortic Arch Calcification Over 1 Year Is an IndependentPredictor of Mortality in Incident Peritoneal Dialysis Patients

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/483638.do
DOI
10.1371/journal.pone.0048793
Title
Progression of Aortic Arch Calcification Over 1 Year Is an IndependentPredictor of Mortality in Incident Peritoneal Dialysis Patients
Description
This work was supported by the Brain Korea 21 Project for MedicalScience, Yonsei University, by the National Research Foundation of Koreagrant funded by the Korea government (MEST) (No. 2011-0030711), and by agrant of the Korea Healthcare Technology Research & Development project,Ministry of Health and Welfare, Republic of Korea (A102065). The fundershad no role in study design, data collection and analysis, decision topublish, or preparation of the manuscript.
abstract
Backgrounds and Aims: The presence and progression of vascular calcification have been demonstrated as important risk factors for mortality in dialysis patients. However, since the majority of subjects included in most previous studies were hemodialysis patients, limited information was available in peritoneal dialysis (PD) patients. Therefore, the aim of this study was to investigate the prevalence of aortic arch calcification (AoAC) and prognostic value of AoAC progression in PD patients.
Methods: We prospectively determined AoAC by chest X-ray at PD start and after 12 months, and evaluated the impact of AoAC progression on mortality in 415 incident PD patients.
Results: Of 415 patients, 169 patients (40.7%) had AoAC at baseline with a mean of 18.1+/-11.2%. The presence of baseline AoAC was an independent predictor of all-cause [Hazard ratio (HR): 2.181, 95% confidence interval (CI): 1.336-3.561, P = 0.002] and cardiovascular mortality (HR: 3.582, 95% CI: 1.577-8.132, P = 0.002). Among 363 patients with follow-up chest X-rays at 12 months after PD start, the proportion of patients with AoAC progression was significantly higher in patients with baseline AoAC (64.2 vs. 5.3%, P<0.001). Moreover, all-cause and cardiovascular death rates were significantly higher in the progression groups than in the non-progression group (P<0.001). Multivariate Cox analysis revealed that AoAC progression was an independent predictor for all-cause (HR: 2.625, 95% CI: 1.150-5.991, P = 0.022) and cardiovascular mortality (HR: 4.008, 95% CI: 1.079-14.890, P = 0.038) in patients with AoAC at baseline.
Conclusions: The presence and progression of AoAC assessed by chest X-ray were independently associated with unfavorable outcomes in incident PD patients. Regular follow-up by chest X-ray could be a simple and useful method to stratify mortality risk in these patients.
provenance
Made available in Cube on 2018-09-28T14:52:10Z (GMT). No. of bitstreams: 0
language
English
author
Lee, Mi Jung
Shin, Dong Ho
Kim, Seung Jun
Oh, Hyung Jung
Yoo, Dong Eun
Ko, Kwang Il
Koo, Hyang Mo
Kim, Chan Ho
Doh, Fa Mee
Park, Jung Tak
Han, Seung Hyeok
Yoo, Tae-Hyun
Choi, Kyu Hun
Kang, Shin-Wook
orcid
Han, Seung Hyeok/0000-0001-7923-5635; Lee, Mi Jung/0000-0001-8888-029X
accessioned
2018-09-28T14:52:10Z
available
2018-09-28T14:52:10Z
issued
2012
citation
PLOS ONE(7): 11
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/483638.do
Funder
교육과학기술부
Funding Program
선도연구센터지원
Project ID
1345168290
Jurisdiction
Rep.of Korea
Project Name
Identification and Control of the Factors in Metabolic Change and Disease Progression
rights
openAccess
type
article


Files in This Item

There are no attached files.