Progesterone produces antinociceptive and neuroprotective effects inrats with microinjected lysophosphatidic acid in the trigeminal nerveroot

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/483608.do
DOI
10.1186/1744-8069-8-16
Title
Progesterone produces antinociceptive and neuroprotective effects inrats with microinjected lysophosphatidic acid in the trigeminal nerveroot
Description
This research was supported by the Basic Science Research Program of theNational Research Foundation of Korea (NRF) funded by the Ministry ofEducation, Science and Technology (2011-0028238).
abstract
Background: In our present study, we studied the role of demyelination of the trigeminal nerve root in the development of prolonged nociceptive behavior in the trigeminal territory.
Results: Under anesthesia, the Sprague-Dawley rats were mounted onto a stereotaxic frame and 3 mu L of lysophosphatidic acid (LPA, 1 nmol) was injected into the trigeminal nerve root to produce demyelination. This treatment decreased the air-puff thresholds, persisted until postoperative day 130, and then returned to the preoperative levels 160 days after LPA injection. The LPA-treated rats also showed a significant hyper-responsiveness to pin-prick stimulation. We further investigated the antinociceptive and neuroprotective effects of progesterone in rats undergoing demyelination of the trigeminal nerve root. Progesterone (8, 16 mg/kg/day) was administered subcutaneously, beginning on the operative day, for five consecutive days in the LPA-treated rats. Treatment with progesterone produced significant early anti-allodynic effects and delayed prolonged anti-allodynic effects. The expression of protein zero (P0) and peripheral myelin protein 22 (PMP22) were significantly down-regulated in the trigeminal nerve root on postoperative day 5 following LPA injection. This down-regulation of the P0 and PMP22 levels was blocked by progesterone treatment.
Conclusions: These results suggest that progesterone produces antinociceptive effects through neuroprotective action in animals with LPA-induced trigeminal neuropathic pain. Moreover, progesterone has potential utility as a novel therapy for trigeminal neuropathic pain relief at an appropriate managed dose and is therefore a possible future treatment strategy for improving the recovery from injury.
provenance
Made available in Cube on 2018-09-28T14:51:21Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Min Ji
Shin, Hea Jung
Won, Kyoung Ae
Yang, Kui Ye
Ju, Jin Sook
Park, Yoon Yub
Park, Jae Sik
Bae, Yong Cheol
Ahn, Dong Kuk
accessioned
2018-09-28T14:51:21Z
available
2018-09-28T14:51:21Z
issued
2012
citation
MOLECULAR PAIN(8)
issn
1744-8069
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/483608.do
Funder
교육과학기술부
Funding Program
2단계연구중심대학육성(0.5)
Project ID
1345196498
Jurisdiction
Rep.of Korea
Project Name
KNU School of Dentistry BK21
rights
openAccess
subject
Progesterone
Antinociception
Neuroprotection
Trigeminal neuralgia
LPA
type
article


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