Physeal growth arrest after tibial lengthening in achondroplasia 23children followed to skeletal maturity

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/483185.do
DOI
10.3109/17453674.2012.678802
Title
Physeal growth arrest after tibial lengthening in achondroplasia 23children followed to skeletal maturity
Description
This study was supported by a grant from the Korea Healthcare TechnologyR&D Project of the Ministry of Health, Welfare and Family Affairs,Republic of Korea (A110416). We thank Dr Jong-Hoon Kim and Dr Hanna Leefor their help with data analysis, literature review, and manuscriptpreparation.
abstract
Background and purpose Bilateral tibial lengthening has become one of the standard treatments for upper segment-lower segment disproportion and to improve quality of life in achondroplasia. We determined the effect of tibial lengthening on the tibial physis and compared tibial growth that occurred at the physis with that in non-operated patients with acondroplasia.
Methods We performed a retrospective analysis of serial radiographs until skeletal maturity in 23 achondroplasia patients who underwent bilateral tibial lengthening before skeletal maturity (lengthening group L) and 12 achondroplasia patients of similar height and age who did not undergo tibial lengthening (control group C). The mean amount of lengthening of tibia in group L was 9.2 cm (lengthening percentage: 60%) and the mean age at the time of lengthening was 8.2 years. The mean duration of follow-up was 9.8 years.
Results Skeletal maturity (fusion of physis) occurred at 15.2 years in group L and at 16.0 years in group C. The actual length of tibia (without distraction) at skeletal maturity was 238 mm in group L and 277 mm in group C (p = 0.03). The mean growth rates showed a decrease in group L relative to group C from about 2 years after surgery. Physeal closure was most pronounced on the anterolateral proximal tibial physis, with relative preservation of the distal physis.
Interpretation Our findings indicate that physeal growth rate can be disturbed after tibial lengthening in achondroplasia, and a close watch should be kept for such an occurrence-especially when lengthening of more than 50% is attempted.
provenance
Made available in Cube on 2018-09-28T14:40:08Z (GMT). No. of bitstreams: 0
language
English
author
Song, Sang-Heon
Agashe, Mandar Vikas
Huh, Young-Jae
Hwang, Soon-Young
Song, Hae-Ryong
orcid
Song, Sang-Heon/0000-0003-1160-0696
accessioned
2018-09-28T14:40:08Z
available
2018-09-28T14:40:08Z
issued
2012
citation
ACTA ORTHOPAEDICA(83): 3
issn
1745-3674
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/483185.do
Funder
교육과학기술부
Funding Program
2단계연구중심대학육성(0.5)
Project ID
1345196553
Jurisdiction
Rep.of Korea
Project Name
Biomedical Center for Intractable Diseases
rights
openAccess
type
article


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