Nocturnal Hypoxia in ALS Is Related to Cognitive Dysfunction and CanOccur as Clusters of Desaturations

Collection with item attached
2013
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/482423.do
DOI
10.1371/journal.pone.0075324
Title
Nocturnal Hypoxia in ALS Is Related to Cognitive Dysfunction and CanOccur as Clusters of Desaturations
Description
This work was supported by Grant No. 2010-0024351 from the NationalResearch Foundation and by Grant No. 2010-0011008 from the Basic ScienceResearch Program through the National Research Foundation of Korea (NRF)funded by the Ministry of Education, Science and Technology. The fundershad no role in study design, data collection and analysis, decision topublish, or preparation of the manuscript.
abstract
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that leads to progressive weakness of the respiratory and limb muscles. Consequently, most patients with ALS exhibit progressive hypoventilation, which worsens during sleep. The aim of this study was to evaluate the relationship between nocturnal hypoxia and cognitive dysfunction and to assess the pattern of nocturnal hypoxia in patients with ALS.
Method: Twenty-five patients with definite or probable ALS underwent neuropsychologic testing, nocturnal pulse oximetry, and capnography. Patients were grouped according to the presence of nocturnal hypoxia (SpO(2)<95% for >= 10% of the night) and their clinical characteristics and cognitive function were compared.
Results: Compared to patients without nocturnal hypoxia, those with nocturnal hypoxia (n = 10, 40%) had poor memory retention (p = 0.039) and retrieval efficiency (p = 0.045). A cluster-of-desaturation pattern was identified in 7 patients (70%) in the Hypoxia Group.
Conclusions: These results suggest that nocturnal hypoxia can be related to cognitive dysfunction in ALS. In addition, a considerable number of patients with ALS may be exposed to repeated episodes of deoxygenation-reoxygenation (a cluster-of-desaturation pattern) during sleep, which could be associated with the generation of reactive oxygen species. Further studies are required to define the exact causal relationships between these phenomena, the exact manifestations of nocturnal cluster-of-desaturation patterns, and the effect of clusters of desaturation on ALS progression.
provenance
Made available in Cube on 2018-09-28T14:19:28Z (GMT). No. of bitstreams: 0
language
English
author
Park, Su-Yeon
Kim, Sung-Min
Sung, Jung-Joon
Lee, Kyung-Min
Park, Kyung-Seok
Kim, Sang-Yun
Nam, Hyun-woo
Lee, Kwang-Woo
accessioned
2018-09-28T14:19:28Z
available
2018-09-28T14:19:28Z
issued
2013
citation
PLOS ONE(8): 9
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/482423.do
Funder
교육과학기술부
Funding Program
일반연구자지원
Project ID
1345175835
Jurisdiction
Rep.of Korea
Project Name
Role of S-nitrosylated PDI in amyotrophic lateral sclerosis and its effect on SOD1 aggregation
rights
openAccess
type
article


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