LAMMER Kinase LkhA Plays Multiple Roles in the Vegetative Growth andAsexual and Sexual Development of Aspergillus nidulans

Collection with item attached
2013
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/481153.do
DOI
10.1371/journal.pone.0058762
Title
LAMMER Kinase LkhA Plays Multiple Roles in the Vegetative Growth andAsexual and Sexual Development of Aspergillus nidulans
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Education, Science and Technology (2010-0012791). The funders had norole in study design, data collection and analysis, decision to publish,or preparation of the manuscript.
abstract
LAMMER kinase plays pivotal roles in various physiological processes in eukaryotes; however, its function in filamentous fungi is not known. We performed molecular studies on the function of the Aspergillus nidulans LAMMER kinase, LkhA, and report its involvement in multiple developmental processes. The gene for LkhA was highly expressed during reproductive organ development, such as that of conidiophores and cleistothecia. During vegetative growth, the patterns of germ tube emergence and hyphal polarity were changed and septation was increased by lkhA deletion. Northern analyses showed that lkhA regulated the transcription of brlA, csnD, and ppoA, which supported the detrimental effect of lkhA-deletion on asexual and sexual differentiation. LkhA also affected expression of cyclin-dependent kinase NimX(cdc2), a multiple cell cycle regulator, and StuA, an APSES family of fungal transcription factors that play pivotal roles in multiple differentiation processes. Here, for the first time, we present molecular evidence showing that LAMMER kinase is involved in A. nidulans development by modulating the expression of key regulators of developmental processes.
provenance
Made available in Cube on 2018-09-28T13:45:08Z (GMT). No. of bitstreams: 0
language
English
author
Kang, Eun-Hye
Kim, Ji-ae
Oh, Hyun-Woo
Park, Hee-Moon
accessioned
2018-09-28T13:45:08Z
available
2018-09-28T13:45:08Z
issued
2013
citation
PLOS ONE(8): 3
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/481153.do
Funder
교육과학기술부
Funding Program
일반연구자지원
Project ID
1345169585
Jurisdiction
Rep.of Korea
Project Name
Role of LAMMER kinase in MBF-dependent G1/S transcription in fission yeast
rights
openAccess
type
article


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