Increased Intra-Individual Variability of Cognitive Processing inSubjects at Risk Mental State and Schizophrenia Patients

Collection with item attached
2013
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/480631.do
DOI
10.1371/journal.pone.0078354
Title
Increased Intra-Individual Variability of Cognitive Processing inSubjects at Risk Mental State and Schizophrenia Patients
Description
This study was supported by a grant of the National Research Foundationof Korea (NRF) funded by the Korea Government (MEST) (no. 2011-0015639).The funders had no role in study design, data collection and analysis,decision to publish, or preparation of the manuscript.
abstract
Intra-individual variability (IIV) has received recent attention as an indicator of the stability of cognitive functioning that may outperform mean performance in reflecting putative neurobiological abnormalities. Increased IIV is regarded as a core deficit in schizophrenia patients; however, whether this deficit is present in the prodromal phase before the onset of schizophrenia has not been well established. In the present study, we investigated IIV using the stop-signal paradigm in at-risk mental state (ARMS) individuals and in schizophrenia patients. The study included 27 ARMS subjects, 37 schizophrenia patients, and 38 normal controls. The stop-signal task was administered to assess IIV and response inhibition. IIV was estimated by calculating the standard deviation across sub-blocks for the three groups. We observed increased IIV in ARMS subjects and schizophrenia patients compared with normal controls in both the "stop" and the "go" processes even though the mean response inhibition performances were not impaired in the ARMS group. Schizophrenia patients showed impaired response inhibition that was associated with the severity of negative symptoms. Our findings suggest that the analysis of IIV may identify cognitive and clinical features of ARMS that are not detectable by conventional mean performance analysis. The unstable response patterns associated with ARMS may originate from abnormal processing in neural systems caused by alterations in the integrity of functional brain networks and dopamine neuromodulation.
provenance
Made available in Cube on 2018-09-28T13:31:02Z (GMT). No. of bitstreams: 0
language
English
author
Shin, Ye Seul
Kim, Sung Nyun
Shin, Na Young
Jung, Wi Hoon
Hur, Ji-Won
Byun, Min Soo
Jang, Joon Hwan
An, Suk Kyoon
Kwon, Jun Soo
accessioned
2018-09-28T13:31:02Z
available
2018-09-28T13:31:02Z
issued
2013
citation
PLOS ONE(8): 11
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/480631.do
Funder
미래창조과학부
Funding Program
중견연구자지원
Project ID
1345202816
Jurisdiction
Rep.of Korea
Project Name
The mechanism of brain-body interaction on brain plasticity : an integrative neurobiological study on the effects of meditation and exercise in health and disease
rights
openAccess
type
article


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