Grape-Seed Proanthocyanidin Extract as Suppressors of Bone Destructionin Inflammatory Autoimmune Arthritis

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/479650.do
DOI
10.1371/journal.pone.0051377
Title
Grape-Seed Proanthocyanidin Extract as Suppressors of Bone Destructionin Inflammatory Autoimmune Arthritis
Description
This work was supported by a grant (A092258) from the Korea HealthcareTechnology R&D Project, Ministry for Health, Welfare, and FamilyAffairs, Republic of Korea. The funders had no role in study design,data collection and analysis, decision to publish, or preparation of themanuscript.
abstract
Chronic autoimmune inflammation, which is commonly observed in rheumatoid arthritis (RA), disrupts the delicate balance between bone resorption and formation causing thedestruction of the bone and joints. We undertook this study to verify the effects of natural grape-seed proanthocyanidin extract (GSPE), an antioxidant, on chronic inflammation and bone destruction. GSPE administration ameliorated the arthritic symptoms of collagen-induced arthritis (CIA), which are representative of cartilage and bone destruction. GSPE treatment reduced the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells and osteoclast activity and increased differentiation of mature osteoblasts. Receptor activator of NFkB ligand expression in fibroblasts from RA patients was abrogated with GSPE treatment. GSPE blocked human peripheral blood mononuclear cell-derived osteoclastogenesis and acted as an antioxidant. GSPE improved the arthritic manifestations of CIA mice by simultaneously suppressing osteoclast differentiation and promoting osteoblast differentiation. Our results suggest that GSPE may be beneficial for the treatment of inflammation-associated bone destruction.
provenance
Made available in Cube on 2018-09-28T13:05:09Z (GMT). No. of bitstreams: 0
language
English
author
Park, Jin-Sil
Park, Mi-Kyung
Oh, Hye-Joa
Woo, Yun-Ju
Lim, Mi-Ae
Lee, Jong-Ho
Ju, Ji Hyeon
Jung, Young Ok
Lee, Zang Hee
Park, Sung-Hwan
Kim, Ho-Youn
Cho, Mi-La
Min, Jun-Ki
accessioned
2018-09-28T13:05:09Z
available
2018-09-28T13:05:09Z
issued
2012
citation
PLOS ONE(7): 12
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/479650.do
Funder
교육과학기술부
Funding Program
2단계연구중심대학육성(0.5)
Project ID
1345196466
Jurisdiction
Rep.of Korea
Project Name
BK Project Team for Biomedicalscience
rights
openAccess
type
article


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