Effect of Nanopore Length on the Translocation Process of a Biopolymer:Numerical Study

Collection with item attached
2013
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/477756.do
DOI
10.3390/ma6093989
Title
Effect of Nanopore Length on the Translocation Process of a Biopolymer:Numerical Study
Description
This work was supported by the National Research Foundation of Korea(NRF) grant 2009-0083510 funded by the Korea government (MSIP). Thisresearch was also supported by Kyungsung University research grants in2013. We are thankful to Professor Joseph Carrier for reading themanuscript.
abstract
In this study, we simulate the electrophoretic motion of a bio-polymer through a synthetic nanopore in the presence of an external bias voltage by considering the hydrodynamic interactions between the polymer and the fluid explicitly. The motion of the polymer is simulated by 3D Langevin dynamics technique by modeling the polymer as a worm-like-chain, while the hydrodynamic interactions are incorporated by the lattice Boltzmann equation. We report the simulation results for three different lengths of the nanopore. The translocation time increases with the pore length even though the electrophoretic force on the polymer is the same irrespective of the pore length. This is attributed to the fact that the translocation velocity of each bead inside the nanopore decreases with the pore length due to the increased fluid resistance force caused by the increase in the straightened portion of the polymer. We confirmed this using a theoretical formula.
provenance
Made available in Cube on 2018-09-28T12:14:39Z (GMT). No. of bitstreams: 0
language
English
author
Alapati, Suresh
Che, Woo Seong
Suh, Yong Kweon
orcid
Alapati, Suresh/0000-0002-1438-1954
accessioned
2018-09-28T12:14:39Z
available
2018-09-28T12:14:39Z
issued
2013
citation
MATERIALS(6): 9
issn
1996-1944
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/477756.do
Funder
미래창조과학부
Funding Program
선도연구센터지원
Project ID
1345203616
Jurisdiction
Rep.of Korea
Project Name
Multi-phenomena CFD Engineering Research Center
rights
openAccess
subject
translocation motion
bio-polymer
nanopore length
lattice Boltzmannmethod
type
article


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