Comparative evaluation of the biological properties of fibrin for boneregeneration

Collection with item attached
2014
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/476278.do
DOI
10.5483/BMBRep.2014.47.2.156
Title
Comparative evaluation of the biological properties of fibrin for boneregeneration
Description
This study was supported by a grant of the Korean Health Technology R&DProject, Ministry for Health, Welfare & Family Affairs, Republic ofKorea (A101768:KMW). The authors report no conflicts of interest relatedto this study.
abstract
Fibrin is a natural provisional matrix found in wound healing, while type I collagen is a major organic component of bone matrix. Despite the frequent use of fibrin and type I collagen in bone regenerative approaches, their comparative efficacies have not yet been evaluated. In the present study, we compared the effects of fibrin and collagen on the proliferation and differentiation of osteoblasts and protein adsorption. Compared to collagen, fibrin adsorbed approximately 6.7 times more serum fibronectin. Moreover, fibrin allowed the proliferation of larger MC3T3-E1 pre-osteoblasts, especially at a low cell density. Fibrin promoted osteoblast differentiation at higher levels than collagen, as confirmed by Runx2 expression and transcriptional activity, alkaline phosphatase activity, and calcium deposition. The results of the present study suggest that fibrin is superior to collagen in the support of bone regeneration.
provenance
Made available in Cube on 2018-09-28T11:35:15Z (GMT). No. of bitstreams: 0
language
English
author
Oh, Joung-Hwan
Kim, Hye-Jin
Kim, Tae-Il
Woo, Kyung Mi
orcid
Woo, Kyung Mi/0000-0002-2782-1189; KIM, TAE-IL/0000-0003-4087-8021
accessioned
2018-09-28T11:35:15Z
available
2018-09-28T11:35:15Z
issued
2014
citation
BMB REPORTS(47): 2
issn
1976-6696
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/476278.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345228982
Jurisdiction
Rep.of Korea
Project Name
BK21 PLUS Dental Life Science
rights
openAccess
subject
Collagen
Fibrin
Fibronectin
Osteoblast
Protein adsorption
type
article


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