Clinical and Histological Effect of a Low Glycaemic Load Diet inTreatment of Acne Vulgaris in Korean Patients: A Randomized, ControlledTrial

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/476055.do
DOI
10.2340/00015555-1346
Title
Clinical and Histological Effect of a Low Glycaemic Load Diet inTreatment of Acne Vulgaris in Korean Patients: A Randomized, ControlledTrial
Description
This study was supported by a grant of the Korea Healthcare TechnologyR&D Project, Ministry for Health, Welfare & Family Affairs, Republic ofKorea (A090411).
abstract
Recent studies have suggested that dietary factors, specifically glycaemic load, may be involved in the pathogenesis of acne. The aim of this study was to determine the clinical and histological effects on acne lesions of a low glycaemic load diet. A total of 32 patients with mild to moderate acne were randomly assigned to either a low glycaemic load diet or a control group diet, and completed a 10-week, parallel dietary intervention trial. Results indicate successful lowering of the glycaemic load. Subjects within the low glycaemic group demonstrated significant clinical improvement in the number of both non-inflammatory and inflammatory acne lesions. Histopathological examination of skin samples revealed several characteristics, including reduced size of sebaceous glands, decreased inflammation, and reduced expression of sterol regulatory element-binding protein-1, and interleukin-8 in the low glycaemic load group. A reduction in glycaemic load of the diet for 10 weeks resulted in improvements in acne.
provenance
Made available in Cube on 2018-09-28T11:29:14Z (GMT). No. of bitstreams: 0
language
English
author
Kwon, Hyuck Hoon
Yoon, Ji Young
Hong, Jong Soo
Jung, JaeYoon
Park, Mi Sun
Suh, Dae Hun
accessioned
2018-09-28T11:29:14Z
available
2018-09-28T11:29:14Z
issued
2012
citation
ACTA DERMATO-VENEREOLOGICA(92): 3
issn
0001-5555
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/476055.do
Funder
보건복지부
Funding Program
보건의료기술연구개발
Project ID
1355061375
Jurisdiction
Rep.of Korea
Project Name
Epidemiological, clinical and laboratory investigation for the influence of diet and food additives on acne
rights
openAccess
subject
acne
epidemiology
IGF-1
diet
glycaemic load
type
article


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