Characterization of the Fungal Microbiota (Mycobiome) in Healthy andDandruff-Afflicted Human Scalps

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/475922.do
DOI
10.1371/journal.pone.0032847
Title
Characterization of the Fungal Microbiota (Mycobiome) in Healthy andDandruff-Afflicted Human Scalps
Description
This study was supported by a grant of the Korea Healthcare TechnologyResearch & Development Project, Ministry for Health & Welfare, Republicof Korea (A085138). The funders had no role in study design, datacollection and analysis, decision to publish, or preparation of themanuscript.
abstract
The human scalp harbors a vast community of microbial mutualists, the composition of which is difficult to elucidate as many of the microorganisms are not culturable using current culture techniques. Dandruff, a common scalp disorder, is known as a causative factor of a mild seborrheic dermatitis as well as pityriasis versicolor, seborrheic dermatitis, and atopic dermatitis. Lipophilic yeast Malassezia is widely accepted to play a role in dandruff, but relatively few comprehensive studies have been reported. In order to investigate fungal biota and genetic resources of dandruff, we amplified the 26S rRNA gene from samples of healthy scalps and dandruff-afflicted scalps. The sequences were analyzed by a high throughput method using a GS-FLX 454 pyrosequencer. Of the 74,811 total sequence reads, Basidiomycota (Filobasidium spp.) was the most common phylum associated with dandruff. In contrast, Ascomycota (Acremonium spp.) was common in the healthy scalps. Our results elucidate the distribution of fungal communities associated with dandruff and provide new avenues for the potential prevention and treatment of dandruff.
provenance
Made available in Cube on 2018-09-28T11:25:45Z (GMT). No. of bitstreams: 0
language
English
author
Park, Hee Kuk
Ha, Myung-Ho
Park, Sang-Gue
Kim, Myeung Nam
Kim, Beom Joon
Kim, Wonyong
orcid
Park, Heekuk/0000-0001-5815-9717; Kim, Beom Joon/0000-0003-2320-7621
accessioned
2018-09-28T11:25:45Z
available
2018-09-28T11:25:45Z
issued
2012
citation
PLOS ONE(7): 2
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/475922.do
Funder
보건복지부
Funding Program
보건의료기술연구개발
Project ID
1465011195
Jurisdiction
Rep.of Korea
Project Name
Advanced Biomarker Discovery for Urologic Diseases
rights
openAccess
type
article


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