Characterization of Phase Transition in the Thalamocortical Systemduring Anesthesia-Induced Loss of Consciousness

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/475916.do
DOI
10.1371/journal.pone.0050580
Title
Characterization of Phase Transition in the Thalamocortical Systemduring Anesthesia-Induced Loss of Consciousness
Description
This research was supported by the Brain Research Program and BasicScience Research Program through the National Research Foundation fundedby the Ministry of Education, Science and Technology of South Korea(2012-0001414; 2012-0005805). The funders had no role in study design,data collection and analysis, decision to publish, or preparation of themanuscript.
abstract
The thalamocortical system plays a key role in the breakdown or emergence of consciousness, providing bottom-up information delivery from sensory afferents and integrating top-down intracortical and thalamocortical reciprocal signaling. A fundamental and so far unanswered question for cognitive neuroscience remains whether the thalamocortical switch for consciousness works in a discontinuous manner or not. To unveil the nature of thalamocortical system phase transition in conjunction with consciousness transition, ketamine/xylazine was administered unobtrusively to ten mice under a forced working test with motion tracker, and field potentials in the sensory and motor-related cortex and thalamic nuclei were concomitantly collected. Sensory and motor-related thalamocortical networks were found to behave continuously at anesthesia induction and emergence, as evidenced by a sigmoidal response function with respect to anesthetic concentration. Hyperpolarizing and depolarizing susceptibility diverged, and a non-discrete change of transitional probability occurred at transitional regimes, which are hallmarks of continuous phase transition. The hyperpolarization curve as a function of anesthetic concentration demonstrated a hysteresis loop, with a significantly higher anesthetic level for transition to the down state compared to transition to the up state. Together, our findings concerning the nature of phase transition in the thalamocortical system during consciousness transition further elucidate the underlying basis for the ambiguous borderlines between conscious and unconscious brains. Moreover, our novel analysis method can be applied to systematic and quantitative handling of subjective concepts in cognitive neuroscience.
provenance
Made available in Cube on 2018-09-28T11:25:36Z (GMT). No. of bitstreams: 0
language
English
author
Hwang, Eunjin
Kim, Seunghwan
Han, Kyungreem
Choi, Jee Hyun
orcid
KIM, Seunghwan/0000-0002-0563-3902
accessioned
2018-09-28T11:25:36Z
available
2018-09-28T11:25:36Z
issued
2012
citation
PLOS ONE(7): 12
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/475916.do
Funder
교육과학기술부
Funding Program
한국과학기술연구원연구운영비지원
Project ID
1345197037
Jurisdiction
Rep.of Korea
Project Name
복합 기술을 이용한 뇌 기능 연구
rights
openAccess
type
article


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