CDO, an Hh-Coreceptor, Mediates Lung Cancer Cell Proliferation andTumorigenicity through Hedgehog Signaling

Collection with item attached
2014
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/475760.do
DOI
10.1371/journal.pone.0111701
Title
CDO, an Hh-Coreceptor, Mediates Lung Cancer Cell Proliferation andTumorigenicity through Hedgehog Signaling
Description
This work was funded by the National Research Foundation of Korea (NRF)grant funded by the Korea Government (MSIP) (2012R1A1A2005448 to YEL)and (NRF-2011-0017315 to JSK). The funders had no role in study design,data collection and analysis, decision to publish, or preparation of themanuscript.
abstract
Hedgehog (Hh) signaling plays essential roles in various developmental processes, and its aberrant regulation results in genetic disorders or malignancies in various tissues. Hyperactivation of Hh signaling is associated with lung cancer development, and there have been extensive efforts to investigate how to control Hh signaling pathway and regulate cancer cell proliferation. In this study we investigated a role of CDO, an Hh co-receptor, in non-small cell lung cancer (NSCLC). Inhibition of Hh signaling by SANT-1 or siCDO in lung cancer cells reduced proliferation and tumorigenicity, along with the decrease in the expression of the Hh components. Histological analysis with NSCLC mouse tissue demonstrated that CDO was expressed in advanced grade of the cancer, and precisely co-localized with GLI1. These data suggest that CDO is required for proliferation and survival of lung cancer cells via Hh signaling.
provenance
Made available in Cube on 2018-09-28T11:21:29Z (GMT). No. of bitstreams: 0
language
English
author
Leem, Young-Eun
Ha, Hye-Lim
Bae, Ju-Hyeon
Baek, Kwan-Hyuck
Kang, Jong-Sun
accessioned
2018-09-28T11:21:29Z
available
2018-09-28T11:21:29Z
issued
2014
citation
PLOS ONE(9): 11
issn
1932-6203
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/475760.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345228983
Jurisdiction
Rep.of Korea
Project Name
21st Century Biomedical Sciences Leader Development Program
rights
openAccess
type
article


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