Arctium lappa ameliorates endothelial dysfunction in rats fed with highfat/cholesterol diets

Collection with item attached
2012
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/475042.do
DOI
10.1186/1472-6882-12-116
Title
Arctium lappa ameliorates endothelial dysfunction in rats fed with highfat/cholesterol diets
Description
This research was supported by Basic Science Research Program throughthe National Research Foundation of Korea (NRF) funded by the Ministryof Education, Science and Technology (MEST) (No. 2010-0029465), and agrant [K10040] to Dr. DG Kang funded by Korea Institute of OrientalMedicine.
abstract
Background: Arctium lappa L. (Asteraceae), burdock, is a medicinal plant that is popularly used for treating hypertension, gout, hepatitis, and other inflammatory disorders. This study was performed to test the effect of ethanol extract of Arctium lappa L. (EAL) seeds on vascular reactivity and inflammatory factors in rats fed a high fat/cholesterol diet (HFCD).
Method: EAL-I (100 mg.kg(-1)/day), EAL-II (200 mg.kg(-1)/day), and fluvastatin (3 mg.kg(-1)/day) groups initially received HFCD alone for 8 weeks, with EAL supplementation provided during the final 6 weeks.
Results: Treatment with low or high doses of EAL markedly attenuated plasma levels of triglycerides and augmented plasma levels of high-density lipoprotein (HDL) in HFCD-fed rats. Chronic treatment with EAL markedly reduced impairments of acetylcholine (ACh)-induced relaxation of aortic rings. Furthermore, chronic treatment with EAL significantly lowered systolic blood pressure (SBP) and maintained smooth and flexible intimal endothelial layers in HFCD-fed rats. Chronic treatment with EAL suppressed upregulation of intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, and E-selectin in the aorta. Chronic treatment with EAL also suppressed increases in matrix metalloproteinase (MMP)-2 expression. These results suggested that EAL can inhibit HFCD-induced vascular inflammation in the rat model.
Conclusion: The present study provides evidence that EAL ameliorates HFCD-induced vascular dysfunction through protection of vascular relaxation and suppression of vascular inflammation.
provenance
Made available in Cube on 2018-09-28T11:02:15Z (GMT). No. of bitstreams: 0
language
English
author
Lee, Yun Jung
Choi, Deok Ho
Cho, Guk Hyun
Kim, Jin Sook
Kang, Dae Gill
Lee, Ho Sub
accessioned
2018-09-28T11:02:15Z
available
2018-09-28T11:02:15Z
issued
2012
citation
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE(12)
issn
1472-6882
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/475042.do
Funder
교육과학기술부
Funding Program
한국한의학연구원연구운영비지원
Project ID
1345195024
Jurisdiction
Rep.of Korea
Project Name
한약을 이용한 당뇨합병증 질환 예방 및 치료제 연구
rights
openAccess
subject
Arctium lappa
Hyperlipidemia
Hypertension
Vasorelaxation
Inflammation
type
article


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