An Evaluation of the in vivo Safety of Nonporous Silica Nanoparticles:Ocular Topical Administration versus Oral Administration

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474588.do
DOI
10.1038/s41598-017-08843-9
Title
An Evaluation of the in vivo Safety of Nonporous Silica Nanoparticles:Ocular Topical Administration versus Oral Administration
Description
This study was supported by a grant from the Korea Health Technology R&DProject through the Korea Health Industry Development Institute, fundedby the Ministry of Health and Welfare, Republic of Korea (grant number:HI-15C1653). It was also supported by the Basic Science Research Programthrough the National Research Foundation of Korea, funded by theMinistry of Education (grant number: 2016R1D1A1B03931724).
abstract
Nonporous silica nanoparticles (SiNPs) have potential as promising carriers for ophthalmic drugs. However, the in vivo safety of ocular topical SiNPs remains unclear. This study investigated the in vivo safety of oral and ocular topical applications of 100 nm-sized SiNPs in Sprague-Dawley rats. The rats were divided into the following four groups: low-dose oral administration (total 100 mg/kg of SiNPs mixed with food for one week), high-dose oral administration (total 1000 mg/kg of SiNPs mixed with food for one week), ocular topical administration (10 mg/ml concentration, one drop, applied to the right eyes four times a day for one month), or a negative control (no SiNP treatment). The rats were observed for 12 weeks to investigate any signs of general or ocular toxicity. During the observation period, no differences were observed in the body weights, food and water intakes, behaviors and abnormal symptoms of the four groups. No animal deaths occurred. After 12 weeks, hematologic, blood biochemical parameters and ophthalmic examinations revealed no abnormal findings in any of the animals. The lack of toxicity of the SiNPs was further verified in autopsy findings of brain, liver, lung, spleen, heart, kidneys, intestine, eyeballs, and ovaries or testes.
provenance
Made available in Cube on 2018-09-28T10:50:00Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Martha
Park, Joo-Hee
Jeong, Hyejoong
Hong, Jinkee
Choi, Woo Sung
Lee, Byung-Han
Park, Choul Yong
accessioned
2018-09-28T10:50:00Z
available
2018-09-28T10:50:00Z
issued
2017
citation
SCIENTIFIC REPORTS(7)
issn
2045-2322
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474588.do
Funder
보건복지부
Funding Program
의료기기기술개발
Project ID
1465024115
Jurisdiction
Rep.of Korea
Project Name
Safety and efficay assay by using nitric oxide nanoparticle and hyaluronic acid composite (smart-composite membrane)
rights
openAccess
type
article


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