Amphotericin B, an Anti-Fungal Medication, Directly Increases theCytotoxicity of NK Cells

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474494.do
DOI
10.3390/ijms18061262
Title
Amphotericin B, an Anti-Fungal Medication, Directly Increases theCytotoxicity of NK Cells
Description
This study was supported by grants from the Korean Healthy TechnologyR&D Project, Ministry of Health & Welfare, Republic of Korea(HI17C0501); Basic Science Research Program through the NationalResearch Foundation of Korea (NRF) funded by the Ministry of Education,Science and Technology (2016R1A2B4010300); the Asan Institute for LifeSciences, Seoul, Korea (17-515).
abstract
Immunomodulatory drugs (IMiDs) present one example of immunomodulatory agents that improve cancer immunotherapy. Based on the cytotoxic activity of natural killer (NK) cells against cancer cells, a high throughput screening method for the identification of novel immunomodulatory molecules with the potential to stimulate NK cell cytotoxicity against cancer cells was designed and tested using an approved drug library. Among the primary hit compounds, the anti-fungal drug amphotericin B (AMP-B) increased the cytotoxicity of NK cell line and human primary NK cells in a direct manner. The increase in NK cell activity was related to increased formation of NK-target cell conjugates and the subsequent granule polarization toward target cells. The results of the present study indicate that AMP-B could serve a dual function as an anti-fungal and immunomodulatory drug.
provenance
Made available in Cube on 2018-09-28T10:47:32Z (GMT). No. of bitstreams: 0
language
English
author
Kim, Nayoung
Choi, Ji-Wan
Park, Hye-Ran
Kim, Inki
Kim, Hun Sik
accessioned
2018-09-28T10:47:32Z
available
2018-09-28T10:47:32Z
issued
2017
citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(18): 6
issn
1422-0067
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474494.do
Funder
보건복지부
Funding Program
질환극복기술개발
Project ID
1465023521
Jurisdiction
Rep.of Korea
Project Name
Autophagy in the pathogenesis of eosinophilic chronic rhinosinusitis: its role and therapeutic potential
rights
openAccess
subject
immunomodulatory drugs
library screening
amphotericin B
naturalkiller cells
cytotoxicity
type
article


Files in This Item

There are no attached files.