Ameliorative effects of pine bark extract on cisplatin-induced acutekidney injury in rats

Collection with item attached
2017
Item details URL
http://open-repository.kisti.re.kr/cube/handle/open_repository/474482.do
DOI
10.1080/0886022X.2017.1282871
Title
Ameliorative effects of pine bark extract on cisplatin-induced acutekidney injury in rats
Description
This study was financially supported by Chonnam National University,2014. This research was also supported by a grant from the KRIBBResearch Initiative Program, Republic of Korea (KGM2221723).
abstract
Objective: This study investigated the dose-response effects of pine bark extract (PBE, pycnogenol((R))) on oxidative stress-mediated apoptotic changes induced by cisplatin (Csp) in rats.
Materials and methods: The ameliorating potential of PBE was evaluated after orally administering PBE at doses of 10 or 20 mg/kg for 10 days. Acute kidney injury was induced by a single intraperitoneal injection of Csp at 7 mg/kg on test day 5.
Results: Csp treatment caused acute kidney injury manifested by elevated levels of serum blood urea nitrogen (BUN) and creatinine (CRE) with corresponding histopathological changes, including degeneration of tubular epithelial cells, hyaline casts in the tubular lumen, and inflammatory cell infiltration (interstitial nephritis). Csp also induced significant apoptotic changes in renal tubular cells. In addition, Csp treatment induced high levels of oxidative stress, as evidenced by an increased level of malondialdehyde, depletion of the reduced glutathione (GSH) content, and decreased activities of glutathione S-transferase, superoxide dismutase, and catalase in kidney tissues. On the contrary, PBE treatment lowered BUN and CRE levels and effectively attenuated histopathological alterations and apoptotic changes induced by Csp. Additionally, treatment with PBE suppressed lipid peroxidation, prevented depletion of GSH, and enhanced activities of the antioxidant enzymes in kidney tissue.
Conclusions: These results indicate that PBE has a cytoprotective effect against oxidative stress-mediated apoptotic changes caused by Csp in the rat kidney, which may be attributed to both increase of antioxidant enzyme activities and inhibition of lipid peroxidation.
provenance
Made available in Cube on 2018-09-28T10:47:14Z (GMT). No. of bitstreams: 0
language
English
author
Lee, In-Chul
Ko, Je-Won
Park, Sung-Hyeuk
Shin, Na-Rae
Shin, In-Sik
Kim, Yun-Bae
Kim, Jong-Choon
accessioned
2018-09-28T10:47:14Z
available
2018-09-28T10:47:14Z
issued
2017
citation
RENAL FAILURE(39): 1
issn
0886-022X
uri
http://open-repository.kisti.re.kr/cube/handle/open_repository/474482.do
Funder
교육부
Funding Program
BK21플러스사업(0.5)
Project ID
1345274331
Jurisdiction
Rep.of Korea
Project Name
Global-bio Human Resource Center for Disease-control
rights
openAccess
subject
Cisplatin
acute kidney injury
apoptosis
oxidative stress
pine barkextract
protective effect
type
article


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